Multi-administration core-shell microneedle patch and preparation method thereof

Abstract

The invention relates to a multi-administration core-shell microneedle patch and a preparation method thereof. The core-shell microneedle patch comprises a core-shell microstructure generated by a 3D manufacturing process that assembles together three different components of the microneedle, including a microneedle shell, a microneedle cap and a dry drug or vaccine core. The microneedle patch which is inserted at one time and released by delayed rupture is applied to the skin at different controllable time points, the microneedle shell matrix material is unequally biodegraded by the human body from several days to several months, the medicine or vaccine is released, and an immune response similar to injection of the same antigen vaccine for multiple times is initiated. The microneedle is loaded with a large number of protein antigens, can be easily inserted into the skin in a minimally invasive manner, does not cause obvious skin irritation during long-term implantation, and reduces the biohazard of a needle / syringe and the risk of disease transmission. In addition, the obtained microneedle patch administration system also shows good biocompatibility, and shows good potential in transformational medicine.

Description

technical field [0001] The invention relates to the field of microneedle patches, in particular to a microneedle patch and a degradable PCL shell, which can precisely control when the drug is released. The present invention also relates to a method for preparing the degradable drug-loaded microneedle patch product. Background technique [0002] For the treatment to be effective, we must strictly adhere to a specific dosing schedule. Many vaccines and drugs require multiple injections, which can lead to problems such as poor patient compliance and financial pressure due to the pain, complex injection procedures, and high cost of injections. [0003] For patients in less developed countries, the problem is compounded by limited access to healthcare services. In these places, except for some parents who have difficulty remembering the schedule, taking their children to the medical center to receive multiple booster doses of vaccines is also a test of financial pressure on par...

AI Technical Summary

Problems solved by technology

However, to date, most of the relevant functional microneedles can only provide immediate release or sustained release, which limits their use in vaccination

Immediate-release microneedles only provide burst release of the vaccine on day 0 after administration. At the same time, the vaccine antigen persists in the body, so sustained-release microneedles may cause immune tolerance problems to the vaccine

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