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Tip-enhanced Raman device

A tip-enhanced Raman and probe technology, applied in measuring devices, Raman scattering, instruments, etc., can solve the problems of not achieving high sensitivity, high resolution and non-destructiveness, and achieve the effect of improving spatial resolution

Inactive Publication Date: 2021-11-19
SHANDONG NORMAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the inventors found that the needle-tip-enhanced Raman devices at the single-molecule level in the prior art cannot meet the requirements of high sensitivity, high resolution, and nondestructiveness.

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  • Tip-enhanced Raman device
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Embodiment Construction

[0030] It should be pointed out that the following detailed description is exemplary and intended to provide further explanation to the present application. Unless defined otherwise, all technical and scientific terms used in this application have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

[0031] It should be noted that the terminology used here is only for describing specific implementations, and is not intended to limit the exemplary implementations according to the present application. As used herein, unless the context clearly dictates otherwise, the singular is intended to include the plural, and it should also be understood that when the terms "comprising" and / or "comprising" are used in this specification, they mean There are features, steps, operations, means, components and / or combinations thereof.

[0032] The present invention will be further explained and illustrated below in conjunction with sp...

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Abstract

The invention relates to the technical field of tip-enhanced Raman scattering (TERS), in particular to a tip-enhanced Raman device which sequentially comprises a metal substrate and a metal probe from bottom to top, wherein the top end of the tip of the metal probe is only provided with a single metal atom. According to the tip-enhanced Raman device, a metal substrate is added, incident laser is incident, and a surface plasmon field which oscillates periodically is generated on the metal surface, so that a Raman detection signal is enhanced; by adopting the tip enhanced Raman technology of the metal probe, due to the addition of the tip, a highly local surface plasmon field is formed on the metal surface, and the single-molecule-level spatial resolution is further achieved; and the tip-enhanced Raman device can improve spatial resolution, when a single lung cancer cell is detected, the spatial range of the single cancer cell is 0.1-10 microns, the device can reach the sub-nanometer level, and the aggregation condition of the single lung cancer cell can be completely and accurately detected.

Description

technical field [0001] The invention relates to the technical field of tip-enhanced Raman scattering (TERS), in particular to a tip-enhanced Raman device. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] For a long time, human beings have been adhering to the principle of "seeing is believing", and optical imaging has been widely used in surface science, molecular nanotechnology, and biotechnology. [0004] Raman spectroscopy is based on the Raman scattering effect discovered by Indian scientist Raman, which is a kind of scattering spectroscopy. Analyze the scattering spectra of different incident light frequencies to obtain molecular vibration and rotation information. ...

Claims

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Application Information

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IPC IPC(8): G01N21/65G01N21/01
CPCG01N21/658G01N21/01G01N2201/06113
Inventor 张凯谢震
Owner SHANDONG NORMAL UNIV
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