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Kit for diagnosing and treating malignant female germ cell tumors

A technology of germ cells and therapeutic reagents, applied in the field of biomedicine, can solve problems such as impact, and achieve the effect of reducing chemotherapy, early prediction, and optimizing treatment plan

Active Publication Date: 2021-11-23
普瑞基准科技(北京)有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Despite numerous studies of cancer genomics signatures in recent years, the genomic signatures of YSTs, tumor evolution patterns, and mechanisms associated with chemotherapy resistance remain largely unknown, thereby affecting the development of new diagnostics, treatments, and treatments. strategy process

Method used

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  • Kit for diagnosing and treating malignant female germ cell tumors
  • Kit for diagnosing and treating malignant female germ cell tumors
  • Kit for diagnosing and treating malignant female germ cell tumors

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Experimental program
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Embodiment 1

[0031] 1 Experimental method

[0032] 1.1 Patient selection and sample cohort

[0033] The 30 YST patients in this study were recruited from Peking Union Medical College Hospital, China. This study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Peking Union Medical College Hospital (project number: JS-1747). All patients should provide written informed consent before treatment, collection and analysis. The pathological characteristics of the 30 patients were rigorously assessed by multiple independent senior pathologists according to standard criteria.

[0034] All YST patients except P14 and P22 were treated with surgery followed by standard platinum-based chemotherapy. Because of the very high tumor burden at P14 and P22, chemotherapy was given before starting standard therapy, as described above. A complete response to initial therapy was defined as satisfactory surgical resection, negative tumor markers, and no ...

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Abstract

The invention relates to a kit for diagnosing and treating malignant female germ cell tumors. The kit comprises a detection reagent for OVOL2 expression level and a cis-platinum drug for chemotherapy. By adopting the kit for diagnosing and treating the female malignant germ cell tumor, the sensitivity degree of the female malignant germ cell tumor to cis-platinum chemotherapy can be predicted in advance, so that a treatment scheme is optimized, unnecessary chemotherapy is reduced, and the prognosis of a patient is improved while the life quality of the patient is improved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a kit for diagnosing and treating female malignant germ cell tumors and its application. Background technique [0002] Yolk sac tumors (YSTs) are a common histological subtype of malignant ovarian germ cell tumors (MOGCTs), which are more common in adolescents and young women, and alpha-fetoprotein (AFP) is a specific tumor marker. The vast majority of YSTs showed primitive extraembryonic structures and reticular microcystic structures histomorphologically, which were the most common diagnostic features. Because the morphology of Schiller-Duval bodies is similar to endodermal sinus in mouse placenta, YSTs are also called endodermal sinus tumors. Similar to other MOGCTs, the standard treatment for YSTs is surgery and cisplatin-based chemotherapy. Although >80% of patients with MOGCTs can survive long-term after regular treatment, patients with YSTs have a rela...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/158C12Q2600/106C12Q2600/118
Inventor 杨佳欣张颖彭鑫鑫季序我
Owner 普瑞基准科技(北京)有限公司
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