Traditional Chinese medicine extract gel for treating allergic rhinitis and preparation method thereof
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A technology for allergic rhinitis and extracts, which is applied in the field of traditional Chinese medicine extract gel and its preparation for the treatment of allergic rhinitis, which can solve the problems of single prescription and low bioavailability of allergic rhinitis, and achieve long retention time in the nasal cavity, High bioavailability and fast onset of effect
Pending Publication Date: 2021-12-03
QUFU NORMAL UNIV
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[0005] Aiming at the problems in the prior art of preventing and treating allergic rhinitis with single prescription and low bioavailability, the present invention provides a traditional Chinese medicine ext
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[0027] Example 1
[0028] Preventing and treating the formulation of gels of allergic rhinitis, including the following part of the component:
[0031] (1) After the mixture of Astragalus, Atractylodes, Board, Bluegen, and Soil, 60 g of pharmaceutical grade sesame oil and 0.24 g inositol hexamide, resulting in a mixture, warming the mixture to 80-90 ° C, stand for 6 hours , Filtration, collecting filtrate;
[0032] (2) Add 60 g of pharmaceutically acceptable grade sesame oil again, stir well, and then rank to 80-90 ° C, continue to allow for 6 hours, filtrate, collect the filtrate;
[0033] (3) 12 ml, 2 g / L of poly γ-glutamic acid solution is added to 50 mL at a rate of 6 ml / h, and the mass fraction of pH = 6 is 3% CS aqueous Cs, and the mixture is stirred while adding, and 1 ml was added dropwise, aqueous solution of citric acid solution of 15%, ultrasonic 10min, ...
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[0035] Example 2
[0036] Preventing and treating the formulation of gels of allergic rhinitis, including the following part of the component:
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Abstract
The invention belongs to the field of high polymer materials, and particularly relates to traditional Chinese medicine extract gel for treating allergic rhinitis and a preparation method thereof. The gel provided by the invention is prepared by taking poly gamma-glutamic acid/chitosan as a carrier and loading a traditional Chinese medicine extract, wherein the traditional Chinese medicine extract is sesame oil extract of astragalus membranaceus, bighead atractylodes rhizome, isatis root and divaricate saposhnikovia root. The traditional Chinese medicine extract gel overcomes the defect that in the prior art, a traditional Chinese medicine for preventing and treating allergic rhinitis is single in formula, multiple traditional Chinese medicines are combined, and all the raw materials play a synergistic effect; and by adopting sesame oil extraction, active ingredients of traditional Chinese medicinal materials in the prescription can be completely extracted, the product is high in active ingredient content and low in impurity content, the extraction process provided by the invention greatly reduces peculiar smell of the traditional Chinese medicinal materials, is good in acceptability, obvious in curative effect and free of toxic and side effects, and directly acts on a focus part through nasal administration, and the traditional Chinese medicine extract gel is high in bioavailability, quick in effect, convenient to use, good in patient compliance and soft in medicine property, and does not cause drug-induced rhinitis.
Description
technical field [0001] The invention belongs to the field of polymer materials, and in particular relates to a traditional Chinese medicine extract gel for treating allergic rhinitis and a preparation method thereof. Background technique [0002] The occurrence of allergic rhinitis is related to many factors such as genetics, environment, and diet. The traditional treatment methods include the use of antihistamine drugs to improve nasal symptoms, allergen desensitization treatment, and nasal cleaning agents. [0003] Western medicine treatment of rhinitis is the most commonly used antihistamine antiallergic drugs, desensitization and nasal cleaning. There are certain defects in the above methods. For example, the use of antihistamine antiallergic drugs to treat allergic rhinitis has certain side effects. After long-term use, there is dependence, the nasal cavity is more likely to dry, and the duration is short, so long-term use is required; allergen desensitization is used. ...
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