Target particle size emulsified cross-linked sodium hyaluronate particle enrichment and cross-linking agent cleaning method
A cross-linked hyaluronic acid and sodium hyaluronate technology, which is applied in the field of medical materials, can solve the problem of difficult cleaning of cross-linking agents, wide particle size distribution of sodium hyaluronate particles, and restrictions on the application of emulsified cross-linked sodium hyaluronate particles and other issues to achieve the effect of saving materials
Pending Publication Date: 2021-12-03
HANGZHOU SINGCLEAN MEDICAL PROD
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Abstract
The invention discloses atarget particle size emulsified cross-linked sodium hyaluronate particle enrichment and cross-linking agent cleaning method, and is used for enriching 15-100 [mu] m emulsified cross-linked sodium hyaluronate particles and cleaning the cross-linking agent. The method comprises the following steps: taking absolute ethyl alcohol as a solvent, enriching emulsified cross-linked sodium hyaluronate particles with the particle size of less than 100mu m through a method of stirring, standing for layering and collecting an upper suspension, and then removing absolute ethyl alcohol through a 0.45 mu m negative pressure filtering device. Meanwhile, absolute ethyl alcohol is adopted for cleaning residual cross-linking agent vinyl sulfone (DVS), and a target product is obtained after vacuum drying. By adopting the method, the emulsified cross-linked sodium hyaluronate particles with target particle size can be directly obtained, the process is simple and convenient, the efficiency is high, and the enrichment effect is good; meanwhile, absolute ethyl alcohol is used for cleaning residues of the cross-linking agent, material consumption is reduced, the cleaning time is greatly shortened, and the DVS cleaning effect is extremely good. The method relates to the technical field of medical materials, and particularly has great application prospects in the preparation process of injection cross-linked sodium hyaluronate materials for plastic surgery.
Technology Topic
Sodium hyaluronateSolvent +8
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