Collagen implant and preparation method thereof

Abstract

The invention provides a collagen implant and a preparation method thereof, and relates to the field of beauty. The collagen implant comprises the following components: collagen fibers and a phosphate buffer solution with the pH value of 7. The invention also provides a preparation method of the collagen fibers, the collagen molecules obtained by adopting the method provided by the invention have a fiber structure with a clear shape after self-aggregation, each fiber is completely exposed and mutually staggered to form a fiber web, and meanwhile, the periodic cross grain D band of the collagen fiber can be clearly observed, and a better fiber form can be formed, and the molecular regularity is higher; the collagen fibers are uniform in thickness and have better elastic strength; besides, the collagen implant is the first material source which is prepared from achilles tendon collagen and can be safely traced to the source through a block chain in the whole world, a virus inactivation pretreatment technology and a precise enzyme digestion telopeptide removal technology are adopted, potential allergy risks can be completely removed, and the prepared implant has a more natural shaping filling effect and a long in-vivo degradation period.

Description

technical field [0001] The invention relates to the cosmetic field, in particular, the invention relates to a collagen implant and a preparation method thereof. Background technique [0002] With the development of society and economy and the improvement of people's living standards, people pay more and more attention to their own image. How to keep the face youthful has become one of the focuses of modern people, and dermal fillers are the most eye-catching restoration in the current society. Youthful technology. An ideal soft tissue injectable implant should have readily available raw materials, good biocompatibility and stability, be safe, reliable, adaptable, less traumatic and have a long lasting effect, without allergy testing, and without adverse reactions. It has the advantages of convenient operation and long storage time, but the related products on the market are not the most ideal injectable implants. [0003] Injectable filler materials currently available in ...

AI Technical Summary

Problems solved by technology

The disadvantage is that although the primary structure of its collagen is basically similar to the primary structure of human collagen and animal-derived collagen, that is, the Gly-X-Y collagen peptide chain, the secondary structure of collagen is destroyed during gene expression. It does not have a natural collagen triple helix structure, and its molecular weight is about 90KD, so it does not have a filling effect

[0015] For example, Chinese patent application 201710383159.X discloses a collagen implant, which includes: 2-8% collagen, 0.1-0.5% additives, and the balance of phosphate physiological buffer, in terms of weight percentage. The collagen used is recombinant human collagen obtained by microbial fermentation. Since the secondary structure of collagen is destroyed during gene expression, it does not have a natural collagen triple helix structure, so the filling effect is poor

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