Application of SUZ12 mediating undifferentiated thyroid cancer cell dedifferentiation

A SUZ12, thyroid cancer technology, applied in the field of basic medicine, can solve the problem of unclear influence of differentiation ability

Inactive Publication Date: 2021-12-10
ZHEJIANG CANCER HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, although some studies have pointed out that ASPM is highly expressed in ATC through gene chips, the effect of ASPM on the differentiation ability of ATC cells is still unclear.

Method used

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  • Application of SUZ12 mediating undifferentiated thyroid cancer cell dedifferentiation
  • Application of SUZ12 mediating undifferentiated thyroid cancer cell dedifferentiation
  • Application of SUZ12 mediating undifferentiated thyroid cancer cell dedifferentiation

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Embodiment Construction

[0027] The present invention will be described in detail below in conjunction with the accompanying drawings and specific implementation steps. The implementation steps are only used to explain the present invention, and are not limited to the present invention. The methods used in the following implementation steps are conventional operations unless otherwise specified, and the materials and reagents can be purchased from the market unless otherwise specified.

[0028] 1 Materials and methods

[0029] 1.1 Reagents and cells

[0030] RPMI-1640 cell culture medium and neonatal bovine bovine serum were purchased from Gibico, USA; ASPM knockout plasmids, SUZ12 overexpression and knockout plasmids were purchased from Jiangsu Aibimeng Biotechnology Co., Ltd.; anti-ASPM, anti-TSHR, Anti-NIS and anti-SUZ12 antibodies were purchased from CST Company in the United States, anti-GAPDH and secondary antibodies were purchased from Lianke Biotechnology Co., Ltd.; Lipofectamine3000 was purc...

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Abstract

The invention provides an application of SUZ12 as a tumor target in treatment of undifferentiated thyroid. Regulation of epithelial-mesenchymal transition (EMT) of cancer cells can be promoted by knocking out the SUZ12, migration and invasion of the cells are inhibited, and the anti-tumor effect is achieved. The SUZ12 can be used as a potential target spot of undifferentiated thyroid cancer and is used as a direction of development of a medicine for treating the undifferentiated thyroid cancer.

Description

technical field [0001] The invention belongs to the technical field of basic medicine, and specifically relates to the application of SUZ12 inhibition in the treatment of undifferentiated thyroid cancer. Background technique [0002] Undifferentiated thyroid cancer (Anaplastic Thyroid Carcinoma, ATC) refers to partially differentiated thyroid cancer during its natural development or after radioactive 131I treatment, tumor cell dedifferentiation leads to a significant decrease or loss of tumor iodine uptake ability, manifested as tumor cell proliferation Accelerated, enhanced invasion and metastasis, leading to poor prognosis. ATC is the most malignant and aggressive type of thyroid tumors. Although the incidence rate is not high, the median survival period after diagnosis is only 3 to 5 months, and the 5-year survival rate is less than 10%. At present, the treatment effect of ATC is poor. In addition to commonly used surgery, radiotherapy and chemotherapy, gene therapy and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G01N33/574G01N33/68C12N15/85C12N5/10A61K45/00A61P35/00
CPCC12Q1/6886G01N33/57407G01N33/57484G01N33/68C12N15/85C12N5/0693C12N5/0617A61K45/00A61P35/00C12Q2600/158C12Q2600/118C12Q2600/136G01N2333/4704C12N2800/107C12N2510/00
Inventor 方琦璐方罗辛文秀李清林戚雅君方美玉曹君舒琦
Owner ZHEJIANG CANCER HOSPITAL
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