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Thermal activation force-electricity synergistic dressing for accelerating wound healing and preparation method

A wound healing and thermal activation technology, applied in dressings, electrotherapy, viscous dressings, etc., can solve the problems of promoting wound healing, single, no electro-mechanical co-stimulation, etc., to inhibit the formation of scabs, promote the healing process, and promote the wound surface. closed effect

Pending Publication Date: 2021-12-14
UNIV OF ELECTRONIC SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current existing technologies all use a single force intervention or electrical intervention for physical therapy, and there is no solution for force and electricity co-stimulation to promote wound healing

Method used

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  • Thermal activation force-electricity synergistic dressing for accelerating wound healing and preparation method
  • Thermal activation force-electricity synergistic dressing for accelerating wound healing and preparation method
  • Thermal activation force-electricity synergistic dressing for accelerating wound healing and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Taking Lidian synergistic dressings adapted to linear wounds as an example, the flexible material is Ecoflex material.

[0052] The unit structure of the mechanical superstructure mesh skeleton pattern area of ​​the electromechanical synergistic dressing is as follows: figure 2 (a) As shown in the figure on the right, the unit structure is an up-down and left-right axisymmetric figure, which is specifically obtained by connecting two transverse M openings, named shape memory alloy mesh L-type (SMA-L). When the bottom side length is 1.8mm and the line width is 0.18mm, the unit structure can be adjusted by adjusting the angle α between the bottom side length and the hypotenuse and the height l between the upper and lower bottom sides.

[0053] Schematic diagram of electrostatic electret film structure of Lidian synergistic dressing image 3 As shown in (a), the positive electrode area separated by the electrostatic electret film is a concentric rectangular ring, and the...

Embodiment 2

[0057] Take the application of Lidian synergy dressing for circular wounds as an example.

[0058] The unit structure of the mechanical superstructure mesh skeleton pattern area of ​​the electromechanical synergistic dressing is as follows: figure 2 (b) As shown in the figure on the right, the unit structure is a rotationally symmetrical figure, which is a ring structure obtained by connecting the basic figures end to end. The basic figures are S-like, consisting of three straight lines and two circular arcs alternately connected , named shape memory alloy mesh type C (SMA-C). When the width and radius of the arc are 0.12mm and 0.41mm respectively, and the width and length of the straight line are 0.24mm and 1.18mm, the corresponding angle β of the arc can be adjusted to adjust the unit structure.

[0059] Schematic diagram of electrostatic electret film structure of Lidian synergistic dressing image 3 As shown in (b), the positive electrode area separated by the electrost...

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Abstract

The invention provides a thermal activation force-electricity synergistic dressing for accelerating wound healing and a preparation method, and belongs to the technical field of biological materials. According to the dressing, a shape memory alloy superstructure with the phase change temperature lower than the body surface temperature of a human body is selected as a dressing framework and is combined with an electrostatic electret, and secretion of related typical growth factors such as fibroblast growth factors, transforming growth factors and vascular endothelial growth factors can be effectively promoted through force-electricity synergistic multi-field stimulation. Meanwhile, an electrostatic field provided by the electrostatic electret can be bactericidal, so that the wound surface microenvironment is adjusted, wound surface closing and metabolism are promoted, scabbing formation is inhibited, and the function of accelerating wound healing through force-electricity synergy at the body temperature is achieved.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a heat-activated electrokinetic synergistic dressing for accelerating wound healing and a preparation method thereof. Background technique [0002] Skin wounds, the result of disruption of tissue integrity caused by extreme external factors, are currently an important issue in public health. With the great progress of modern biomedical technology, drug-based (inflammation-suppressing drugs, growth factor-mediated, etc.) developed rapidly. The current mainstream wound healing solution is based on pharmacological treatment, which is treated by smearing. However, pharmacological treatment has the problems of rapid drug degradation and easy loss of activity. For non-pharmacological wound treatment strategies, although most non-invasive physical intervention treatment strategies such as compression bandages, negative pressure therapy, and electrical stimulation ther...

Claims

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Application Information

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IPC IPC(8): A61F13/02A61F13/00A61N1/10
CPCA61F13/0236A61F13/00051A61F13/00987A61N1/10A61F13/01034A61F13/01017A61F13/01008A61F13/01021
Inventor 姚光尹晨晖莫小艺娄文豪黄思荣毛琳娜潘泰松高敏林媛
Owner UNIV OF ELECTRONIC SCI & TECH OF CHINA
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