Thermal activation force-electricity synergistic dressing for accelerating wound healing and preparation method

A wound healing and thermal activation technology, applied in dressings, electrotherapy, viscous dressings, etc., can solve the problems of promoting wound healing, single, no electro-mechanical co-stimulation, etc., to inhibit the formation of scabs, promote the healing process, and promote the wound surface. closed effect

Pending Publication Date: 2021-12-14
UNIV OF ELECTRONIC SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the current existing technologies all use a single force intervention or electrical intervention for

Method used

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  • Thermal activation force-electricity synergistic dressing for accelerating wound healing and preparation method
  • Thermal activation force-electricity synergistic dressing for accelerating wound healing and preparation method
  • Thermal activation force-electricity synergistic dressing for accelerating wound healing and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0050] Example 1

[0051] Adapted to linear wound as an example with force electrical coordination, and flexible materials use EcoFlex material.

[0052] The mechanical super structural mesh skeleton pattern area of ​​force electricity collaborative dressing figure 2 (a) As shown in the right, the unit structure is up and down, the left and right axis-aliametric pattern, and is specifically connected to the opening of the two lateral M, named shape memory alloy mesh L type (SMA-L). When the bottom edge is 1.8 mm, when the line width is 0.18 mm, the angle α between the bottom edge length and the opposite side can be adjusted to adjust the unit structure.

[0053] Structure of electrostatic electret thin film structure of force electricity synergistic dressing image 3 As shown in (a), the positive electrode region separated by the electrostatic electret film is a concentric rectangular ring, the negative electrode region is rectangular, the finite element electric field distribution...

Example Embodiment

[0056] Example 2

[0057] Adapted to the circular wound as an example with force electrical coordination dressing.

[0058] The mechanical super structural mesh skeleton pattern area of ​​force electricity collaborative dressing figure 2 (b) As shown in the right, the unit structure is a rotational axis symmetric graphic, a ring structure obtained by the first tail of the base graphic, the base pattern, which is formed, and three-stage straight line and two arc alternate connectivity. Named the shape memory alloy grid C type (SMA-C). When the width and radius of the circular arc is from 0.12 mm and 0.41 mm, the width and length of the line is 0.24 mm and 1.18 mm, the arc corresponds to the angle β can be adjusted to adjust the unit structure.

[0059] Structure of electrostatic electret thin film structure of force electricity synergistic dressing image 3 (b), the positive electrode region separated by the electrostatic electret film is a circular ring, the negative electrode regi...

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Abstract

The invention provides a thermal activation force-electricity synergistic dressing for accelerating wound healing and a preparation method, and belongs to the technical field of biological materials. According to the dressing, a shape memory alloy superstructure with the phase change temperature lower than the body surface temperature of a human body is selected as a dressing framework and is combined with an electrostatic electret, and secretion of related typical growth factors such as fibroblast growth factors, transforming growth factors and vascular endothelial growth factors can be effectively promoted through force-electricity synergistic multi-field stimulation. Meanwhile, an electrostatic field provided by the electrostatic electret can be bactericidal, so that the wound surface microenvironment is adjusted, wound surface closing and metabolism are promoted, scabbing formation is inhibited, and the function of accelerating wound healing through force-electricity synergy at the body temperature is achieved.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a heat-activated electrokinetic synergistic dressing for accelerating wound healing and a preparation method thereof. Background technique [0002] Skin wounds, the result of disruption of tissue integrity caused by extreme external factors, are currently an important issue in public health. With the great progress of modern biomedical technology, drug-based (inflammation-suppressing drugs, growth factor-mediated, etc.) developed rapidly. The current mainstream wound healing solution is based on pharmacological treatment, which is treated by smearing. However, pharmacological treatment has the problems of rapid drug degradation and easy loss of activity. For non-pharmacological wound treatment strategies, although most non-invasive physical intervention treatment strategies such as compression bandages, negative pressure therapy, and electrical stimulation ther...

Claims

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Application Information

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IPC IPC(8): A61F13/02A61F13/00A61N1/10
CPCA61F13/0236A61F13/00008A61F13/00017A61F13/00021A61F13/00034A61F13/00051A61F13/00987A61N1/10
Inventor 姚光尹晨晖莫小艺娄文豪黄思荣毛琳娜潘泰松高敏林媛
Owner UNIV OF ELECTRONIC SCI & TECH OF CHINA
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