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Method for screening traditional Chinese medicine composition with network targeting effect from molecular level

A technology of molecular level and composition, applied in the direction of drug combination, drug reference, medical formula, etc., can solve the problems of low clinical efficiency of traditional Chinese medicine, can not reveal the mechanism of drug action and scientific essence from the essence, and achieve clear mechanism and therapeutic target. point clear effect

Pending Publication Date: 2021-12-17
华子昂
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AI Technical Summary

Problems solved by technology

Although the principle of compatibility of monarch, subject and assistant envoy formed under the theory of traditional Chinese medicine is orderly, it cannot reveal the mechanism of action and the scientific nature of the drug from the essence. Therefore, the clinical efficacy of traditional Chinese medicine is low.

Method used

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  • Method for screening traditional Chinese medicine composition with network targeting effect from molecular level
  • Method for screening traditional Chinese medicine composition with network targeting effect from molecular level
  • Method for screening traditional Chinese medicine composition with network targeting effect from molecular level

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Embodiment 1

[0020] The invention provides a method for screening a traditional Chinese medicine composition with a network targeting effect from the molecular level, which includes the following steps.

[0021] genetic data analysis

[0022] In the Therapeutic Target Database (TTD, http: / / db.idrblab.net / ttd / ) search for endometriosis related genes: AR, ESR1, ESR2, CYP19A1, CNR2, PPARG, PTGS1, STS, PGR, GNRHR, IFNAR2, LHCGR, PTGER2, PTGS2, IL10, P2RX3, P2RX4.

[0023] Protein Interaction Analysis

[0024] Convert disease-related gene names into Official Gene Symbols and input them into STRING 11.0 database (https: / / string-db.org / ) to build a PPI network, such as figure 1 shown. The comprehensive score of the interaction between each protein is shown in Table 1, with an average of 0.653; according to the comprehensive score of protein interaction in the network, the sequence of disease-related genes is obtained: ESR1, PGR, CYP19A1, ESR2, LHCGR, PTGER2, AR, P2RX4, P2RX3, PTGS2, PTGS1, IL...

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Abstract

Although the compatibility principle of monarch, minister, assistant and guide formed under the traditional Chinese medicine theory is ordered, the action mechanism and scientific essence of the medicine cannot be revealed from essence, and the clinical effective rate of the traditional Chinese medicine is low. Therefore, the invention provides a method for screening the traditional Chinese medicine composition with the network targeting effect from the molecular level, the correlation between the disease symptom and the traditional Chinese medicine symptom is established from the molecular level through gene data analysis and traditional Chinese medicine data analysis, so that a traditional Chinese medicine action network with clear targeting and clear mechanism is obtained, and finally a network targeting formula is formed. A new thought is provided for research and development and action mechanism research of new traditional Chinese medicines, and modernization and internationalization of traditional Chinese medicines are assisted.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a method for screening a traditional Chinese medicine composition with a network targeting effect from a molecular level. Background technique [0002] According to the theory of traditional Chinese medicine, the prescription rules of traditional Chinese medicine follow the rule of "the monarch, ministers and assistants". Twenty kinds are assistants, mainly treating diseases; the medicine must be combined with the ruler and ministers." In the Yuan Dynasty, Li Gao stated in "On the Spleen and Stomach": "The king's medicine is the most, the minister's medicine is the second, and the minister's medicine is the second. Don't let the ministers be more than the emperor, the emperor and the ministers are orderly, and they can protect against evil and eliminate diseases. That's it." Jun refers to the medicine in the prescription that plays the main therapeutic rol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H70/40G16B20/00G16C20/30A61K36/804A61P15/00
CPCG16H70/40G16B20/00G16C20/30A61K36/236A61K36/232A61K36/66A61K36/486A61K36/537A61K36/286A61K36/752A61K36/754A61K36/36A61K36/346A61K36/539A61K36/804A61K36/46A61K36/64A61K36/284A61K36/233A61P15/00A61K2300/00
Inventor 华子昂朱美瑛刘宝全竹添孙宁万君兴
Owner 华子昂
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