Application of BAG3 inhibitor in preparation of products for treating scars

Abstract

The invention relates to the field of medicines, in particular to application of a BAG3 inhibitor in preparation of a product for treating scars. The BAG3 inhibitor disclosed by the invention is clear in treatment target, and avoids the defects of unclear treatment mechanism, low efficiency, easiness in causing side effects and the like; a series of side effects possibly caused by hormone therapy are also avoided; normal cells of a human body cannot be damaged; new scar formation cannot be induced; large-area pathological scars can be treated; compared with the existing medicine, the medicine provided by the invention has a remarkable advantage in cost and is relatively low in synthesis cost.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the use of a BAG3 inhibitor in the preparation of a product for treating scars. Background technique [0002] Hypertrophic scar is a common complication after wound / burn healing, which not only affects the patient's appearance, but also causes different degrees of functional impairment, such as tendon contracture, joint dislocation, and motor dysfunction, which seriously reduces the quality of life of patients. Later treatment brings a heavy economic and psychological burden. According to statistics, the incidence of hypertrophic scar after burn is 91.4%. If the healing time of burn wound is more than 2 weeks, the incidence of hypertrophic scar is as high as 74.67%. The research on the prevention and treatment of scar is an ancient and novel topic. Studies have found that scarring is an excessive healing response of the human body to trauma, leading to a fibrometabolic disease in the de...

AI Technical Summary

Problems solved by technology

The limitations of the existing methods of prevention and treatment of pathological scars mainly include: 1. Surgical treatment: the treatment process is painful, the recurrence rate is high, and it is not suitable for patients with large area scars; 2. Pressure therapy: the effect is better for patients with large area burns , but the patient needs to wear an elastic compression device for a long time, causing serious inconvenience to life; 3. Radiotherapy: the therapeutic effect is limited, and often causes permanent radiation damage to the patient's whole body and local area; 4. Cryotherapy: only suitable for small scars, And treatment can cause skin pigmentation, skin atrophy and other complications; 5. Glucocorticoid treatment: can produce complications such as skin atrophy, telangiectasia, osteoporosis, female menstrual disorders, ulceration or calcification at the injection site; 6. Laser Therapy: low effective rate, easy to induce new scars; 7. Antineoplastic drug therapy (5-FU, etc.): it is also highly toxic to normal cells, and the clinical value is not yet clear; 8. Tacrolimus, statins Similar drugs, tamoxifen and other drugs: the clinical efficacy is limited, and the therapeutic target is not yet clear

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