Use of the siRNA molecular composition in the preparation of medicines targeting hdac5 to inhibit scar formation

Abstract

The present invention proposes the use of a siRNA molecular composition in the preparation of drugs for inhibiting scar formation against HDAC5; the sequence of the siRNA molecular composition is: sense strand: 5'-CAG-CAU-GAC-CAC-CUG-ACA ‑ATT‑3' antisense strand: 5'‑UUG‑UCA‑GGU‑GGU‑CAU‑GCU‑GTT‑3'. The drug treatment target of the present invention is clear, avoiding the shortcomings of unknown treatment mechanism, low efficiency, and easy side effects; avoiding a series of side effects that may be caused by hormones; avoiding the possibility of damaging normal cells of the human body; compared with laser therapy, It avoids the shortcoming of shallow treatment depth and the possibility of inducing new scar formation; compared with surgical treatment and cryotherapy, it can treat large areas of pathological scars, and avoids the shortcoming of small treatment range.

Description

technical field [0001] The present invention relates to the field of medicine application, in particular to the application of siRNA molecular composition in preparing medicine for inhibiting scar formation against HDAC5. Background technique [0002] Hypertrophic scar is a fibrotic skin disease, which is a fibrous metabolic disease of the skin dermis characterized by uncontrolled proliferation of fibroblasts and excessive production and deposition of a large amount of extracellular matrix such as collagen. It affects the physical and mental health of millions of people worldwide. Usually secondary to trauma, burns, and surgery. It has been reported that the incidence rate in patients after conventional surgery is 36-64%, and the incidence rate in patients with deep burns can be as high as 91%. Hypertrophic scars not only affect the appearance of patients, but also lead to varying degrees of dysfunction and seriously reduce the quality of life of patients. [0003] A larg...

AI Technical Summary

Problems solved by technology

The limitations of the existing methods of preventing and treating pathological scars mainly include: 1. Surgical therapy, the treatment process is painful, the recurrence rate is high, and it cannot be applied to patients with large scars; The effect is better for patients with surface burns, but patients need to wear elastic compression devices for a long time, which seriously inconveniences their lives; 3. Radiation therapy, the therapeutic effect is limited, and often causes permanent radiation damage to the patient's whole body and local area; 4. Cryotherapy, only applicable 5. Glucocorticoid treatment can cause skin atrophy, depigmentation, telangiectasia, female menstrual disorders, and ulceration at the injection site or calcification and other complications; 6. Laser therapy, the clinical efficiency is low, and it is easy to induce new scars; 7. Antineoplastic drug therapy is highly toxic to local and systemic normal cells, and the clinical value is not yet clear; Limus, statins, tamoxifen and other drugs have limited clinical efficacy, and the therapeutic targets are not yet clear

Images