Application of LMK235 in medicine for inhibiting scar formation

Abstract

The invention provides application of LMK235 in a medicine for inhibiting scar formation. Application of LMK235 as a medicine for treating hypertrophic scars is proposed for the first time. Injectionof LMK235 into the scars has obvious effects of inhibiting formation of the hypertrophic scars. The related medicine is clear in therapeutic target, and the defects that therapeutic mechanisms are unknown, the efficiency is low, side effects are easily caused, and the like are overcome; a series of side effects which can be brought by hormones are avoided; the probability of damage to normal humancells is avoided; the defect of shallow treatment depth is overcome, and the probability of induced formation of new scars is avoided; and large-area pathological scars can be treated, so that the defect of a small treatment scope is overcome.

Description

technical field [0001] The present invention relates to the field of application of LMK235, in particular to the application of LMK235 in drugs for inhibiting scar formation. Background technique [0002] Hypertrophic scar is a fibrotic skin disease, which is a fibrous metabolic disease of the skin dermis characterized by uncontrolled proliferation of fibroblasts and excessive production and deposition of a large amount of extracellular matrix such as collagen. It affects the physical and mental health of millions of people worldwide. Usually secondary to trauma, burns, and surgery. It has been reported that the incidence rate in patients after conventional surgery is 36-64%, and the incidence rate in patients with deep burns can be as high as 91%. Hypertrophic scars not only affect the appearance of patients, but also lead to varying degrees of dysfunction and seriously reduce the quality of life of patients. [0003] A large amount of clinical evidence shows that hypert...

AI Technical Summary

Problems solved by technology

The limitations of the existing methods of preventing and treating pathological scars mainly include: 1. Surgical therapy, the treatment process is painful, the recurrence rate is high, and it cannot be applied to patients with large scars; 2. Compression therapy and silicone product treatment are not suitable for large The effect is better for patients with surface burns, but patients need to wear elastic compression devices for a long time, which seriously inconveniences their lives; 3. Radiation therapy, the therapeutic effect is limited, and often causes permanent radiation damage to the patient's whole body and local area; 4. Cryotherapy, only applicable 5. Glucocorticoid treatment can cause skin atrophy, depigmentation, telangiectasia, female menstrual disorders, and ulceration at the injection site or calcification and other complications; 6. Laser therapy, the clinical efficiency is low, and it is easy to induce new scars; 7. Antineoplastic drug therapy is highly toxic to local and systemic normal cells, and the clinical value is not yet clear; Limus, statins, tamoxifen and other drugs have limited clinical efficacy, and the therapeutic targets are not yet clear

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