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Composition and application of a drug action target

A technology of drug action and composition, applied in the biological field, can solve the problems of inaccurate treatment targets, limited clinical curative effect, high recurrence rate, etc., to achieve the purpose of inhibiting the proliferation of skin fibroblasts, evading the shallow treatment depth, and clear treatment targets Effect

Active Publication Date: 2021-04-09
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Limitations of existing prevention and treatment methods for pathological scars: surgical therapy has a high recurrence rate and cannot be applied to patients with large-area scars; compression therapy and silicone products are effective for patients with large-area burns, but only For early prevention, the curative effect on scars that have formed is limited; radiation therapy can cause certain radiation damage to the patient's whole body and local area; cryotherapy is only suitable for small scars, and the treatment can cause skin pigmentation and mild skin atrophy and other complications; glucocorticoid treatment may cause complications such as skin atrophy, depigmentation, telangiectasia, female menstrual disorders, ulceration or calcification at the injection site; laser therapy has a low clinical effective rate and is likely to induce new scars; Antineoplastic drug therapy has a great impact on normal cell metabolism, and the clinical value is not yet clear; tacrolimus, statins, tamoxifen and other drugs have limited clinical efficacy, and the therapeutic target is not yet clear

Method used

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  • Composition and application of a drug action target
  • Composition and application of a drug action target
  • Composition and application of a drug action target

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Experimental program
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Embodiment 1

[0032] 1. Experimental materials

[0033] 1.1 Small nucleotide sequence

[0034] Small interfering RNA (siRNA): It is a small RNA molecule (~21-25 nucleotides), which is processed by Dicer (an enzyme specific to double-stranded RNA in the RNAase III family). SiRNA is the main member of siRISC, which stimulates the silencing of its complementary target mRNA. RNA interference (RNAi) refers to the specific degradation of intracellular mRNA mediated by endogenous or exogenous double-stranded RNA (dsRNA), resulting in the silencing of the expression of target genes and the loss of corresponding functional phenotypes .

[0035] Its sequence against human FKBP10mRNA is:

[0036] Sense strand: 5'-GAAGGAAGAUUAUCAUCCCCUCCAUU-3';

[0037] Antisense strand: 5'-AAUGGAGGGAUGAUAAUCUUCCUUC-3';

[0038] Its sequence against mouse FKBP10 mRNA is:

[0039] Sense strand: 5'-CCACACCUACAAUACCUAUTT-3';

[0040] Antisense strand: 5'-AUAGGUAUUGUAGGUGUGGTT-3';

[0041] Its sequence against human ...

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Abstract

The invention relates to a composition and application of a drug action target. The composition includes a carrier and a drug using FKBP10 and PCOLCE genes and / or their encoded proteins as the drug action target. The present invention inhibits the formation of tissue fibrosis by interfering with FKBP10 and PCOLCE, and inhibits biological behaviors such as proliferation, differentiation, anti-apoptosis, and secretion of a large amount of extracellular matrix of skin fibroblasts, thereby achieving the effect of treating fibrosis-related diseases.

Description

technical field [0001] The invention belongs to the field of biotechnology, in particular to a composition and application of a drug action target. Background technique [0002] Pathological scar is a skin fibrotic disease that exists all over the world, and its incidence rate varies among different races. Previous reports mentioned that the incidence of pathological scar in the Caucasian population ranges from 5% to 37%. , the incidence rate in patients after conventional surgery is 36-64%, and the incidence rate in deep burn patients can be as high as 91%. Pathological scars are caused by traumatic inflammatory responses, etc., and are characterized by uncontrolled proliferation of fibroblasts (Fb) and excessive production and deposition of a large amount of extracellular matrix (ECM) such as collagen. Metabolic diseases are clinically manifested as scar tissue above the skin surface that does not exceed the scope of the wound, with obvious early congestion, which may be ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61P17/00
CPCA61K45/00A61P17/02C12Y502/01008C12N15/1137C12N2310/14C12N15/113C12N2320/31A61K9/0019A61K47/42C12N2320/32
Inventor 李青峰梁筱黄晓璐柴邦达
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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