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Medicine for repairing intestinal mucosa and improving mucosa immune function and preparation method of medicine

A technology of immune function and mucous membrane, which is applied to the medicine for repairing intestinal mucosal damage and its preparation, and improves the immune function of chicken intestinal mucosa. It can solve the problems of simple and rough production process, low technological content of products, and unstable quality. Relieve the symptoms of bloody diarrhea, restore absorption and digestion function, repair and improve the effect

Pending Publication Date: 2021-12-21
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing pharmaceutical preparations cannot improve the immune function of intestinal mucosa, repair intestinal mucosal damage and improve production performance. In addition, the research level of most anti-coccidian traditional Chinese medicine preparations is low, and most of them are simple mixing, crushing and extraction of traditional Chinese medicine raw materials. The production process is simple and rough; secondly, the pharmaceutical preparations fail to release the active ingredients of each raw material, the product technology content is low, and the quality is not stable enough, and it has a great improvement in improving the immune function of the intestinal mucosa and repairing the damaged intestinal mucosa space

Method used

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  • Medicine for repairing intestinal mucosa and improving mucosa immune function and preparation method of medicine
  • Medicine for repairing intestinal mucosa and improving mucosa immune function and preparation method of medicine
  • Medicine for repairing intestinal mucosa and improving mucosa immune function and preparation method of medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] In this embodiment, the pharmaceutical composition and preparation method for repairing intestinal mucosa and improving mucosal immunity are prepared according to the following steps:

[0024] (1.1) Weigh 5g of artemisinic acid in parts by weight (1.0g per part), 8g of quinine hydrochloride in parts by weight, 4g of Shuqi extract in parts by weight, and weigh in parts by weight Take ghost needle grass extract 6g, take lysozyme 3g by weight parts, citric acid 8g by weight parts, chitosan 10g by weight parts; weigh anhydrous glucose by weight parts 56g; except lysozyme, mix the other components evenly;

[0025] (1.2) Take the mixture obtained in step (1), add sterilized deionized water to 900mL, stir and mix evenly; then add 0.5mL Tween-80, 2.5g benzoic acid and 0.5g paraben in sequence, add sterilized Deionized water to 1000mL place, magnetic stirring and mixing for 15min, adjust the pH value to 5-6 with sodium hydroxide or dilute hydrochloric acid; sterilize and irradiat...

Embodiment 2

[0026] Example 2 In this example, the pharmaceutical composition and preparation method for repairing intestinal mucosa and improving mucosal immunity are prepared according to the following steps:

[0027] (2.1) Weigh 10g of artemisinic acid in parts by weight (1.0g per part), 12g of quinine hydrochloride in parts by weight, and 10g of Shuqi extract by parts by weight, and weigh by parts by weight Get 10g of ghost needle grass extract, weigh 8g of lysozyme by parts by weight, take by weight 15g of citric acid, take by weight of parts of chitosan 20g, take by weight of parts of anhydrous glucose 15g; except lysozyme, mix the other components evenly;

[0028] (2.2) The preparation steps of the pharmaceutical composition and preparation are the same as the step (1.2) of Example 1. Same later.

Embodiment 3

[0029] Example 3 In this example, the pharmaceutical composition and preparation method for repairing intestinal mucosa and improving mucosal immunity are prepared according to the following steps:

[0030] (3.1) Weigh 5g of artemisinic acid in parts by weight (1.0g per part), 12g of quinine hydrochloride in parts by weight, 4g of Shuqi extract in parts by weight, and weigh in parts by weight Get 10g of ghost needle grass extract, weigh 6g of lysozyme by weight, take by weight 10g of citric acid, take by weight of chitosan 15g, take by weight of anhydrous glucose 38g; except lysozyme, mix the other components evenly;

[0031] (3.2) The preparation steps of the pharmaceutical composition and preparation are the same as the step (1.2) of Example 1.

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Abstract

The invention provides a pharmaceutical composition for repairing an intestinal mucosa and improving a mucosa immune function for poultry. The pharmaceutical composition is prepared from the following components in parts by weight: 5 to 10 parts of arteannuic acid, 8 to 12 parts of quinine hydrochloride, 4 to 10 parts of a solanum lyratum extract, 6 to 10 parts of a bidens pilosa extract, 3 to 8 parts of lysozyme, 8 to 15 parts of citric acid, 10 to 20 parts of chitosan and the balance of a carrier. According to the pharmaceutical composition provided by the invention, through protecting a cecum gland structure of an infected chick, the development of intestinal tissues is promoted, and the integrity of the intestinal mucosa is protected, so that absorption and digestion functions of intestinal tracts are recovered, and the weight gain rate of chicks is increased; and the proliferation of pathogenic bacteria in the intestinal tracts is reduced through a specific immune way, the local immune function of intestinal mucosa is enhanced, and the healing and recovery of intestinal mucosa injury are promoted. The pharmaceutical composition provided by the invention has a good prevention and treatment effect on intestinal mucosa injury and hemorrhagic diarrhea caused by mixed infection of chicken coccidiosis and secondary colibacillosis.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, and specifically provides a medicine for improving the immune function of the intestinal mucosa of chicks and repairing intestinal mucosal damage and a preparation method thereof. Background technique [0002] Chicken coccidiosis is a common protozoan disease in which Eimeria coccidiosis parasitizes the epithelial cells of the intestinal mucosa of chickens and causes intestinal injury and bleeding. The disease can be seen all year round in intensive farming, and the disease is also very serious in the whole breeding process of ground-raised chickens. Clinical manifestations are characterized by diarrhea, bloody stools, growth retardation, reduced feed remuneration, high morbidity and mortality. After chicks are infected with coccidiosis, the intestinal epithelial cells will be severely damaged, leading to intestinal inflammation and secondary bacterial infection, further aggravating ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/47A61K47/26A61P1/00A61P1/04A61P37/04A61K31/194A61K31/49A61K31/722A61K36/185A61K36/28
CPCA61K31/49A61K36/185A61K36/28A61K38/47C12Y302/01017A61K31/194A61K31/722A61K47/26A61P1/00A61P1/04A61P37/04A61K2300/00
Inventor 王玲郭文柱崔东安郭志廷沙赫巴兹罗永江张彬郭天芬杨峰魏小娟王春梅吕嘉文程峰
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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