The application provides a
traditional Chinese medicine composition for treating or improving Sjogren'
s syndrome, and belongs to the technical field of
traditional Chinese medicine pharmacy.The
traditional Chinese medicine composition takes
asparagus, lily and mulberry as monarch drugs, takes
honeysuckle,
semen astragali, rush and radix
codonopsis as minister drugs, takes turmeric and atractylodes as auxiliary drugs, and takes licorice as a guide
drug, and the drugs are combined to have the effects of nourishing yin and moistening
dryness, clearing heat and dredging collaterals, tonifying qi and invigorating the
spleen, and promoting
blood circulation and improving eyesight.The traditional Chinese
medicine composition can significantly reduce the
water consumption of NOD mice, increase the
saliva amount of NOD mice, significantly down-regulate the levels of
inflammatory factors TNF-alpha, IL-17 and IL-1beta in the serum of NOD mice, improve the
gland structure and
lymphocyte infiltration in the submandibular gland tissue of NOD mice, and reduce the submandibular gland injury.In addition, the traditional Chinese
medicine composition can significantly reduce the ESSDAI and ESSPRI scores of Sjogren'
s syndrome patients, improve the clinical symptoms such as
dry mouth,
dry eyes and salivary gland swelling of the patients, has a high total effective rate in
clinical treatment, and can be further developed and researched as a
drug for treating Sjogren'
s syndrome.