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Mass spectrum combined multichannel electrospray micro-fluidic chip ion source

A microfluidic chip and multi-channel technology, applied in the direction of ion source/gun, circuit, discharge tube, etc., can solve the problem of signal sensitivity enhancement, achieve the effect of improving the detection signal strength, improving ionization efficiency, and reducing the impact

Pending Publication Date: 2021-12-24
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Mass spectrometry adopts the method of simultaneous sample injection and analysis of multi-channel spray chips. Multiple channels generate electrospray at the same time to obtain a large spray volume. does not mean that the signal sensitivity will be enhanced

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  • Mass spectrum combined multichannel electrospray micro-fluidic chip ion source
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  • Mass spectrum combined multichannel electrospray micro-fluidic chip ion source

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Embodiment Construction

[0032] The embodiments of the present invention will be described in detail below. It should be emphasized that the following description is merely exemplary, not to limit the scope of the invention and its application.

[0033] It should be noted that when the element is referred to as "fixed to" or "set to" another element, it can be directly on the other element or indirectly on the other element. When a component is called "connected to" another element, it can be directly connected to another element or indirectly connected to the other element. Additionally, the connection may be either for a fixed action or a coupled or communication.

[0034] It is to be understood that the term "length", "width", "upper", "lower", "front", "post", "right", "vertical", "level", "top" The orientation or position of "bottom" "inside", "outside", etc. is based on the orientation or positional relationship shown in the drawings, is merely intended to describe the embodiments and simplified des...

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Abstract

A mass spectrum combined multichannel electrospray micro-fluidic chip ion source comprises a chip, a first liquid path flow channel, a second liquid path flow channel and a gas path flow channel, wherein the first liquid path flow channel and the second liquid path flow channel are arranged in the chip, and the gas path flow channel is matched with the first liquid path flow channel and the second liquid path flow channel. A first nozzle is formed at the junction of the outlet of the first liquid path flow channel and the outlet of the corresponding gas path flow channel, a second nozzle is formed at the junction of the outlet of the second liquid path flow channel and the outlet of the corresponding gas path flow channel, and the included angle between the spraying direction of the first nozzle and the spraying direction of the second nozzle is 45-55 degrees. The micro-fluidic chip ion source disclosed by the invention can effectively improve the mass spectrum signal intensity and improve the ionization efficiency, and is particularly suitable for implementing a parallel ionization spray function to desorb a sample.

Description

Technical field [0001] The present invention relates to an electrospray ion source, and more particularly to a multi-channel electrospray microfluidic chip ion source for mass spectrometry. Background technique [0002] With the extensive use of chemical development in drug development, and a series of multi-channel ionization technologies for achieving high-throughput analysis as a multi-channel ionization technique for achieving high-throughput analysis. Multi-channel simultaneous injection analysis is developed on the basis of electrospray ionization, and multiple channels simultaneously generate electrospray to obtain a larger spray amount, so that more ionically transferred into mass spectrometry, often used to improve ionization Efficiency and precise quality analysis. Multi-channel spray can enhance signal strength, improve sensitivity, and can achieve efficiency and high flux analysis of macromolecular samples. MAO et al. Designed a multi-nozzle circular array microfluidi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/16
CPCH01J49/165H01J49/167
Inventor 钱翔刘继琳余泉倪凯王晓浩
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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