Arthrobacter sp. and application thereof in degradation of aristolochic acid

A technology of aristolochic acid and Arthrobacter, applied in the field of microorganisms, can solve the problems of unremoved nitro groups, etc., and achieve the effects of fast reproduction rate, complete detoxification and fast growth rate
CN113846038APending Publication Date: 2021-12-28SHANGHAI JIAO TONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI JIAO TONG UNIV
Publication Date
2021-12-28

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Abstract

The invention belongs to the field of microorganisms, and discloses arthrobacter sp. and application thereof in degradation of aristolochic acid. The strain is Arthrobacter sp. NyZ610, and the preservation number of the strain is GDMCC NO: 61799. The strain can degrade aristolochic acid under an aerobic condition, can breed and grow by taking aristolochic acid as a unique carbon, nitrogen and energy raw material, mineralizes aristolochic acid through an oxidation way, removes nitryl and finally decomposes the aristolochic acid into carbon dioxide, water and nitrite, so that complete detoxification / detoxification of aristolochic acid is realized, and the strain can be used for in-situ remediation of aristolochic acid pollution in the environment, can also be used for processing and detoxification of traditional Chinese medicines containing aristolochic acid, and has the advantages of high reproduction rate, complete detoxification and the like.
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Description

technical field

[0001] The invention belongs to the field of microorganisms, and relates to a strain of Arthrobacter sp. NyZ610 and its application in degrading aristolochic acid. The Arthrobacter sp. can reproduce and grow with aristolochic acid as the only carbon, nitrogen and energy raw material. The oxidative pathway mineralizes aristolochic acid, which is accompanied by the removal of the nitro group and the formation of nitrite. Background technique

[0002] Aristolochic acid (AAs) is a nitrophenanthrene organic acid compound, mainly containing aristolochic acid A, aristolochic acid B, etc., naturally occurring in species such as Aristolochia and Asarum and other Aristolochiaceae plants. These plants have been widely processed and detoxified as raw medicinal materials, but long-term use of Chinese herbal medicines containing aristolochic acid and its preparations will cause nephrotoxicity and carcinogenicity. Aristolochic acid has been proven to be related to liver c...

Claims

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