Pharmaceutical composition containing ibuprofen and chlorpheniramine and preparation method of pharmaceutical composition containing ibuprofen and chlorpheniramine
A technology of composition and medicine, which is applied in the field of medicine, can solve problems such as easy knocking of tablets, unqualified content uniformity of phenylephrine hydrochloride and chlorpheniramine maleate, etc., achieve good stability and avoid mutual function, the effect of improving stability
Pending Publication Date: 2022-01-04
山东则正医药技术有限公司
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Problems solved by technology
[0005] One of the problems to be solved in the present invention is how to solve the interaction problem between phenylephrine hydrochloride and chlorpheniramine maleate, thereby improving the stability of phenylephrine hydrochloride
[0006] The second problem to be solved by the present invention is that the hardness of the tablet is too low during the tableting process, and it is easy to knock the tablet, and the content uniformity of phenylephrine hydrochloride and chlorpheniramine maleate in the finished product is unqualified
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0043] Table 1 shows the components and proportioning ratios of the pharmaceutical composition containing prongrenin and iramine in this embodiment.
[0044] Table 1 Example 1 contains the prescription of the pharmaceutical composition of Buprosrenin
[0045]
[0046]
Embodiment 2
[0048] Table 2 shows the components and proportioning ratio of the pharmaceutical composition containing prongrenin and iramine in this embodiment.
[0049] Table 2 embodiment 2 contains the prescription of the pharmaceutical composition of prostaglandin
[0050]
[0051]
Embodiment 3
[0053] Table 3 shows the components and proportioning ratios of the pharmaceutical composition containing prongrenin and iramine in this embodiment.
[0054] Table 3 Example 3 contains the prescription of the pharmaceutical composition of Buprosrenin
[0055]
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Abstract
The invention discloses a pharmaceutical composition containing ibuprofen and chlorpheniramine and a preparation method of the pharmaceutical composition containing ibuprofen and chlorpheniramine. The pharmaceutical composition comprises a core; and the core is of a double-layer structure, one layer is a first layer containing ibuprofen and chlorpheniramine maleate, and the other layer is a second layer containing phenylephrine hydrochloride. The preparation method comprises the following steps: S1, preparing an adhesive; S2, mixing and granulating; S3, drying; S4, total mixing; and S5, tabletting. According to the pharmaceutical composition, the use types of auxiliary materials are reduced, two active medicinal components with interaction are designed in different layers by adopting a double-layer tablet process, the stability of phenylephrine hydrochloride is improved, and the pharmaceutical composition has a wide application prospect.
Description
technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition containing bronvirin and a preparation method thereof. Background technique [0002] Flu is a common disease and frequently-occurring disease. Since cold symptoms include stuffy nose, runny nose, dizziness, headache, cough, swollen throat, and weak limbs, a single drug is often ineffective. Therefore, it is often necessary to use multiple active ingredients together when prescribing the right medicine. The compound preparation can target multiple cold symptoms at the same time, and has the advantage of comprehensive control, and has gradually become the mainstream product in the current market. [0003] Phenylephrine hydrochloride is an α-adrenergic receptor agonist, which has selective vasoconstriction, can relieve the congestion and swelling of nasopharyngeal mucosa, and relieve nasal congestion, runny nose and other symptoms. It is t...
Claims
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Patent Timeline
Login to View More IPC IPC(8): A61K9/28A61K31/4402A61P11/00A61K31/137A61K31/192
CPCA61K9/209A61K9/2054A61K9/2009A61K9/2095A61K9/2893A61K31/192A61K31/4402A61K31/137A61P11/00A61K2300/00
Inventor郭英霞张昊胡愈璋贺敦伟
Owner山东则正医药技术有限公司