Flammulina velutipes sporocarp dietary fiber, and extraction method and application of flammulina velutipes sporocarp dietary fiber in preparation of weight loss drugs or obesity treatment drugs
A technology of dietary fiber and extraction method, which is applied in the field of medicine and/or health care products, can solve the problem of no dietary fiber weight loss effect, and achieve the effect of no toxic and side effects
Active Publication Date: 2022-01-07
HENAN ZHONGDA HENGYUAN BIOTECH CO LTD
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Problems solved by technology
Dietary fiber (Dietary fiber, DF) is called "the seventh largest nutrient" by nutritionists. Flammulina velutipes is very rich in dietary fiber, but there is no report about the weight loss effect of dietary fiber on the fruiting body of Flammulina velutipes
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Embodiment 1
[0026] A kind of dietary fiber of Flammulina velutipes fruit body, which is obtained by extracting through the following extraction method, specifically:
[0027] Clean 5 kg of dried Flammulina velutipes fruiting bodies, cut them into pieces, and then add 25 L of ethanol with a volume concentration of 70% for leaching twice, each time for 3 days. After the residue is dried, weigh the remaining 2593.9g, add 6% sodium hydroxide solution with a mass concentration of 6% according to the ratio of solid to liquid 1g: 20mL, extract at 70°C for 50min, filter, wash the filter residue with distilled water until neutral, dry at 60°C, weigh Weigh 1365g Flammulina velutipes dietary fiber; powder, pass through 80 mesh sieve, set aside.
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The invention relates to an extraction method of flammulina velutipes sporocarp dietary fiber, which comprises the following steps of: cleaning flammulina velutipes sporocarp, performing leaching with ethanol, airing residues, performing leaching with a 2-8% sodium hydroxide solution at 60-80 DEG C, performing filtering, washing the filter residues to be neutral, and performing drying to obtain the flammulina velutipes sporocarp dietary fiber. According to the invention, a rat obesity model is established by using a high-fat feed; the weight, the Lee's index, the BMI and the visceral organ index of a rat are measured; and pathological changes of adipose tissues and livers of the rat are observed through an HE staining method. The weight reduction effect of the flammulina velutipes sporocarp dietary fiber is comprehensively evaluated through the detection indexes. Experimental results prove that the flammulina velutipes sporocarp dietary fiber can effectively reduce the weight, the Lee's index, the BMI and the visceral organ index of the rat and relieve visceral organ injury caused by modeling, and has no toxic or side effect, so that the flammulina velutipes sporocarp dietary fiber disclosed by the invention can be used for preparing health care products or drugs for treating/preventing obesity.
Description
technical field [0001] The invention belongs to the technical field of medicine and / or health products, and in particular relates to a dietary fiber of Flammulina velutipes fruit body, an extraction method and research on weight loss. Background technique [0002] Obesity has become one of the diseases that endanger human health worldwide, 1.1 billion adults and 10% of children are now classified as overweight or obese, and the average life expectancy has been shortened. The main adverse consequences of obesity are cardiovascular disease, type 2 diabetes, and the induction of various cancers. The main symptoms of obesity are thicker waistlines and higher body weight than normal. Accumulated fat will damage the health of the body. Adipose tissue is a heterogeneous mixture composed of adipocytes, stromal preadipocytes, immune cells and endothelial cells. It is a complex secretion system. The factors secreted by fat are collectively referred to as adipokines. The main reason is...
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IPC IPC(8): A61K36/07A61P3/04A23L33/21
CPCA61K36/07A61P3/04A23L33/21A23V2002/00A61K2236/331A23V2200/332A23V2250/208
Inventor 康文艺金子恒王金梅赵青春
Owner HENAN ZHONGDA HENGYUAN BIOTECH CO LTD
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