Prediction model for initial dose of tacrolimus after liver transplantation and individualized application of prediction model

A technology of tacrolimus and initial dose, which is applied in the prediction model of initial dose of tacrolimus after liver transplantation and its individualized application field, achieving high accuracy

Active Publication Date: 2022-01-14
SHANGHAI FIRST PEOPLES HOSPITAL
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There is no report about the prediction model of the initial dose of tacrolimus after liver transplantation and its individualized application in the present invention

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  • Prediction model for initial dose of tacrolimus after liver transplantation and individualized application of prediction model
  • Prediction model for initial dose of tacrolimus after liver transplantation and individualized application of prediction model
  • Prediction model for initial dose of tacrolimus after liver transplantation and individualized application of prediction model

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Embodiment 1

[0049] 1 information

[0050] 1.1 Clinical data

[0051] From January 2015 to December 2017, 150 patients with orthotopic liver transplantation in the First People's Hospital Affiliated to Shanghai Jiaotong University were selected as the development cohort. A total of 97 orthotopic liver transplantation patients admitted to the First Affiliated Hospital of Zhengzhou University from February 2015 to December 2017 were selected as the external validation cohort.

[0052] 1.2 Inclusion criteria

[0053] (1) Patients over 18 years old;

[0054] (2) Orthotopic liver transplantation from a deceased donor;

[0055] (3) The quality of the donated liver is good and meets the standards for transplantation;

[0056] (4) Patients who have signed the informed consent and accepted the tacrolimus-based immunosuppressive regimen.

[0057] 1.3 Exclusion criteria

[0058] (1) Multiple organ transplant patients;

[0059] (2) The follow-up time is less than 1 month;

[0060] (3) The conc...

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Abstract

The invention relates to the technical field of biology, in particular to a prediction model for the initial dose of tacrolimus after liver transplantation and an individualized application of the prediction model. According to the invention, 247 cases of orthotopic liver transplantation patients from 2 transplantation centers are studied, donor and receptor DMET Plus chips are used for screening important sites, and liver genotyping is performed on 150 cases of recipients from the center 1 and livers of corresponding donors of the recipients. Besides, clinical variables are further contained in the model, a tacrolimus pharmacokinetic prediction model is constructed through LASSO regression, results show that AUC in a development queue and AUC in a verification queue are 0.878 and 0.790 respectively, after tacrolimus is given within the recommended concentration range (RCR, 4-10 ng/mL), the incidence rate of new metabolic syndromes is low, and a basis is provided for personalized drug delivery of clinical liver transplantation patients.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a prediction model of the initial dose of tacrolimus after liver transplantation and its individualized application. Background technique [0002] Tacrolimus, a calcineurin inhibitor, is the main immunosuppressive drug after solid organ and hematopoietic stem cell transplantation [1-3] . Sufficient immunosuppression is crucial to suppress rejection and improve transplant survival; excessive immunosuppression can lead to a series of serious adverse drug reactions, such as infection, diabetes, renal insufficiency, etc., and the therapeutic window of tacrolimus is narrow, individual Large inter- and intra-individual variability, complicating routine dose adjustments [4-6] . On the other hand, the dose varies greatly among patients, up to 20 times or more (0.5-10 mg / day), and Chinese patients usually only use half of the dose recommended by current guidelines to maintain immune balanc...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/106C12Q2600/156
Inventor 彭志海刘园张金彦张坤苏昭杰史宝洁王杰王瑞肖毅
Owner SHANGHAI FIRST PEOPLES HOSPITAL
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