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Application of reagent for detecting miRNA expression quantity in preparation of reagent or kit for diagnosis or prognosis of Kazakh hypertension

A technology of expression level and kit, applied in the field of molecular biology diagnosis, can solve problems such as the inability to guarantee the accuracy of hypertension diagnosis

Pending Publication Date: 2022-01-18
SHIHEZI UNIVERSITY
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Problems solved by technology

Therefore, the accuracy of the biomarkers obtained from the Han nationality for the diagnosis of hypertension in ethnic minorities cannot be guaranteed

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  • Application of reagent for detecting miRNA expression quantity in preparation of reagent or kit for diagnosis or prognosis of Kazakh hypertension
  • Application of reagent for detecting miRNA expression quantity in preparation of reagent or kit for diagnosis or prognosis of Kazakh hypertension
  • Application of reagent for detecting miRNA expression quantity in preparation of reagent or kit for diagnosis or prognosis of Kazakh hypertension

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Embodiment 1

[0041] This study screened differential miRNAs and enriched signaling pathways based on bioinformatics methods, combined with multiple databases to predict target genes, and observed miRNA expression profiles in Xinjiang Kazakh patients with essential hypertension. There are differential expressions in patients and healthy Kazakhs. Identifying the targets of these miRNAs and understanding the interaction between miRNAs and mRNAs are the key points to elucidate the mechanism of miRNAs, and further research is needed.

[0042] 1 Materials and methods

[0043] 1.1 Clinical data: From April 2016 to May 2019, 30 Kazakh patients with essential hypertension who visited the Department of Cardiology and Outpatient Department of the First Affiliated Hospital of Shihezi University School of Medicine in Xinjiang were used as the observation group. as the control group. The blood pressure of the research subjects was measured according to the standard measurement method established in the...

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Abstract

The invention provides application of a reagent for detecting miRNA expression quantity in preparation of reagent or kit for diagnosis or prognosis of Kazakh hypertension, and belongs to the technical field of molecular biology diagnosis. The miRNA comprises one or more of the following: hsa-miR-100-5p, hsa-miR-299-5p, hsa-miR-299-3p, hsa-miR-196b-5p, hsa-miR-503-5p, hsa-miR-628-5p, hsa-miR-543, hsa-miR-150-5p, hsa-miR-296-5p, hsa-miR-874-3p and hsa-miR-940. The 11 miRNAs can be used as biomarkers for early diagnosis and prognosis evaluation of Kazakh hypertension clinically, and a new thought is provided for drug targets for hypertension treatment.

Description

technical field [0001] The invention relates to the technical field of molecular biology diagnosis, in particular to the application of a reagent for detecting miRNA expression in the preparation of a reagent or a kit for diagnosing or prognosing Kazak hypertension. Background technique [0002] Hypertension is a disease characterized by elevated arterial blood pressure, often accompanied by target organ damage such as the heart, blood vessels, brain, and kidneys. It is the main risk factor for most cardiovascular and kidney morbidity and death. Hypertension is the result of a combination of genetic and environmental factors. In recent years, scholars at home and abroad have been exploring the pathogenesis of hypertension for a long time, and have intervened in the occurrence and progression of hypertension from the perspective of the mechanism. Although some achievements have been made, the mechanism has not been fully elucidated. [0003] With the progress of research on ...

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Application Information

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IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/178C12Q2600/158
Inventor 马克涛李新芝王彦
Owner SHIHEZI UNIVERSITY