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Formula and preparation technology of pulse-activating decoction solution

A preparation process and Shengmaiyin technology are applied to the formulation of Shengmaiyin solution and the field of preparation technology, and can solve the problems that need to be further investigated and optimized, affect the safety and effectiveness of clinical medication, and uneven product quality.

Pending Publication Date: 2022-01-21
山西卫生健康职业学院
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Shengmaiyin (Dangshen prescription, Shengmaiyin mentioned below are all Dangshen prescriptions) is now recorded in the tenth volume of the Ministry of Standards, which stipulates the preparation method, properties, inspection items, etc. of Shengmaiyin, but, The soaking time, decoction times and time, separation and concentration methods in the production method need to be further investigated and optimized; there are only routine inspection and relative density inspection items under the inspection items, and the product quality of Shengmai Drink has not been effectively controlled, resulting in market The quality of products sold is uneven, which directly affects the safety and effectiveness of clinical medication

Method used

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  • Formula and preparation technology of pulse-activating decoction solution
  • Formula and preparation technology of pulse-activating decoction solution
  • Formula and preparation technology of pulse-activating decoction solution

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experiment example

[0024] Solvent dosage investigation: Precisely weigh the 3 medicinal materials according to the ratio in Shengmai Decoction, add purified water at three levels of 10 times / 8 times, 8 times / 6 times and 7 times / 5 times for the first decoction and the second decoction, respectively. Prepare according to the preparation method of Shengmai Decoction, measure 20mL and dry to constant weight, calculate the ointment rate, take 5mL and inject samples according to the preparation method of the test solution, calculate the content of each index component, use the comprehensive scoring method, comprehensive score = 0.1X 1 / X 1max +0.1X 2 / X 2max +…+0.1X 8 / X 8max +0.1Y / Y max (X 1 ~X 8 5-HMF, syringin, tangshenoside Ⅰ, Lobetylinin, tangshenoside, schisandrin A, schisandra alcohol B, and angeliylgomisin H, respectively, and Y is the paste yield), as can be seen from Table 1. The highest score is when the amount of the second decoction is 10 times / 8 times.

[0025] Table 1 Investigat...

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Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, and discloses a preparation technology of a pulse-activating decoction (radix codonopsis formula) solution. The preparation technology comprises the following steps of precisely weighing radix codonopsis medicinal materials, radix ophiopogonis and fructus schizandrae in a round-bottom flask; adding purified water to soak for 30 minutes; heating and refluxing with an electric jacket; filtering while hot with gauze; adding water into residues; continuously heating and refluxing; filtering with the gauze; combining filtrates obtained in two times; concentrating under reduced pressure to 30 mL; slowly adding absolute ethyl alcohol while stirring; standing overnight; centrifuging to take supernate; concentrating under reduced pressure to a certain volume; and adding water to fix the volume to 50mL to obtain the pulse-activating decoction (radix codonopsis formula) solution. According to the preparation technology of the pulse-activating decoction (radix codonopsis formula) solution, the optimal preparation technology of the pulse-activating decoction (radix codonopsis formula) solution is obtained by accurately operating the treatment technology and time.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a formulation of Shengmaiyin solution and a preparation process thereof. Background technique [0002] Shengmaiyin comes from "Medical Qiyuan", also known as "Shengmaisan", which is composed of ginseng, Ophiopogon japonicus and Schisandra chinensis. It is a representative prescription for the treatment of Qi and Yin deficiency syndrome, and it is also a classic and commonly used prescription in Chinese medicine. Modern pharmacological research results show that Shengmaiyin has good medicinal effects in protecting heart function and improving heart condition. Shengmai Drink (Dangshen Prescription) is derived from the ancient prescription Shengmaisan. The ginseng in the prescription is replaced by Codonopsis pilosula. Taking it is not easy to help fire and obstruct qi, and can be widely used in patients with sub-health and mild chronic cardiovasc...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/08A61P9/00A61P43/00
CPCA61K36/344A61K36/8968A61K36/79A61K36/57A61K9/0095A61P9/00A61P43/00A61K2236/331A61K2236/39A61K2236/53A61K2236/51A61K2300/00
Inventor 朱琳陈素娥刘亮亮安琪侯丽华孙红刘珏玲武林芝
Owner 山西卫生健康职业学院
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