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Method for rapidly predicting dry granulation formability of traditional Chinese medicine formula granules

A technology of traditional Chinese medicine formula granules and dry granulation, which is applied in the preparation of test samples, measuring devices, strength characteristics, etc., and can solve the prediction of failure and inapplicable dry granulation formability, testing cycle and testing cost of Chinese medicine formula granules Unbearable and other problems to achieve the effect of avoiding production waste

Pending Publication Date: 2022-01-25
劲牌持正堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If this method is used, at least 7,500 standard samples are required for 500 commonly used traditional Chinese medicine formula granules, and a large amount of sample data needs to be tested. The detection cycle and detection cost are also unbearable for actual production.
However, once the source of raw materials and production process of traditional Chinese medicine formula granules change slightly, the previous sample model will become invalid, and this method will also fail at the same time.
Therefore, the artificial intelligence fuzzy algorithm is not suitable for the prediction of the dry granulation formability of traditional Chinese medicine formula granules in actual production.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Weigh 0.255-0.260 g of gardenia formula granule dry cream powder, put it into the tableting mold of an infrared tablet machine, press 15 MPa, pressurize for 15-20 seconds, hold for 5 seconds, and take out the tablet core.

[0019] Usually, pharmaceutical production uses a rotary tablet press to prepare tablets, but the actual production maximum pressure of the rotary tablet press is usually below 3MPa, and high-pressure tablet compression cannot be performed. The production of traditional Chinese medicine formula granules usually uses a dry granulator, and the actual maximum production pressure of the roller is above 20MPa, so the rotary tablet press cannot simulate the preparation of the tablet samples of the dry granulator. The infrared tablet machine is an accessory of the infrared spectrometer, not a commonly used tablet pressing equipment. The actual maximum pressure for preparing tablet cores exceeds 25MPa, and the effective pressure range is basically the same as ...

Embodiment 2

[0022] Weigh 0.255-0.260g dry paste powder of drynaria formula granules, put it into the tabletting mold of an infrared tablet machine, press 15MPa, pressurize for 15-20 seconds, hold for 5 seconds, take out the core, and use the tablet The hardness tester measures the core hardness, and the result is 117N. It is predicted that the moldability of drynaria dry paste powder of this batch belongs to a good range. The parameters for determining the dry granulation molding are pressure: 10-15MPa, and the production speed of the equipment is set at a medium speed (roller speed 12-15r / min).

Embodiment 3

[0024] Weigh 0.255-0.260g of rhubarb formula granule dry cream powder, put it into the tableting mold of an infrared tablet machine, press 15MPa, increase the pressure for 15-20 seconds, hold the pressure for 5 seconds, take out the tablet core, and test it with a tablet hardness tester The core hardness was measured and found to be 165N. It is predicted that the moldability of this batch of rhubarb dry paste powder belongs to a very good range. The parameters for determining the dry granulation molding are pressure: 5-10MPa, and the production speed of the equipment is set at high speed (roller speed 18-20r / min).

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Abstract

The invention discloses a method for rapidly predicting the dry granulation formability of traditional Chinese medicine formula granules, which comprises the following steps: S1, weighing formula granule dry paste powder, putting the formula granule dry paste powder into a tabletting mold of an infrared tabletting machine, and carrying out pressure forming; S2, taking out the tablet core, and measuring the hardness of the tablet core by using a tablet hardness tester; and S3, predicting whether dry granulation molding can be carried out or not based on a tablet core hardness result. According to the invention, the dry granulation formability of the traditional Chinese medicine formula granule dry paste powder can be simply, conveniently, rapidly and accurately predicted, and the experiment cost and the detection period are greatly reduced.

Description

technical field [0001] The invention belongs to the technical field of formula preparation of traditional Chinese medicine granules, and in particular relates to a method for quickly predicting the dry granulation formability of traditional Chinese medicine formula granules. Background technique [0002] The raw material for dry granulation of traditional Chinese medicine formula granules is dry cream powder. In actual production, the problem of low formability of dry granulation often occurs due to the difference in physical properties of dry paste powder. In order to avoid unnecessary increase in production costs caused by temporary shutdown of dry granulation, and to provide quantitative basis for adjustment of process parameters of dry granulation machine, it is necessary to use a simple method to quantitatively predict the formation of dry paste powder dry granulation in advance sex. [0003] The dry granulator used in the dry granulation of traditional Chinese medici...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/28G01N3/40
CPCG01N1/286G01N3/40G01N2203/0076
Inventor 郑元涛石炳光徐小青吴建辉王委李斌
Owner 劲牌持正堂药业有限公司
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