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Construction method of corpus callosum cut-off animal model

A technology of animal models and construction methods, which is applied in the fields of medical science, veterinary instruments, veterinary surgery, etc., can solve the problems of difficult operation, less animal models, and more venous sinus bleeding, etc. The effect of less damage and less bleeding

Pending Publication Date: 2022-01-28
中国人民解放军陆军特色医学中心
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are very few animal models, and most of the existing cutting methods use surgical blades to cut, which will cause great damage to the local brain tissue, cause more bleeding in the venous sinuses, and are not easy to operate

Method used

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  • Construction method of corpus callosum cut-off animal model
  • Construction method of corpus callosum cut-off animal model
  • Construction method of corpus callosum cut-off animal model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Construction method of animal model of corpus callosum section

[0019] After the mouse was anesthetized with 1.5% pentobarbital sodium, the brain was fixed on a stereotaxic instrument, the skin on the top of the skull was prepared, disinfected with iodine, the skin was incised at the midline of the top with a scalpel, and the skin on both sides was fixed with skin clips to expose the top skull. Use a marker pen to draw a straight line parallel to the midline at 0.5 mm to the left of the midline of the skull ( figure 1 shown), anteriorly to 2mm anterior to the sagittal suture, and posteriorly to 2.7mm posterior to the sagittal suture. Use a micro-drill to cut a bone suture parallel to the midline along the drawn line. The depth is just to penetrate the periosteum, about 0.6mm. There is a sense of void when penetrating, and the pia mater and brain parenchyma should not be injured. With a tiny cotton ball soaked in saline, wipe away bone debris.

[0020] The mouse skull...

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Abstract

The invention relates to a construction method of a corpus callosum cut-off animal model, and belongs to the field of animal model research. According to the construction method of the corpus callosum cut-off animal model, damage to local brain tissue is small, bleeding is little, the operation method is easy to master, and the constructed animal model of the corpus callosum cut-off animal model can be applied to research of epilepsy treatment and has wide application prospects.

Description

technical field [0001] The invention belongs to the field of animal model research, and in particular relates to a method for constructing a corpus callosum cut animal model. Background technique [0002] The corpus callosum is a bundle of fibers connecting the left and right cerebral hemispheres. Severing the corpus callosum between the left and right brains of patients with severe epilepsy can alleviate the epilepsy, but it will also cause some complications due to the loss of connection between the sensory and motor functions of the two hemispheres, such as split-brain syndrome. Gradually improve, a few are permanent. During the evolution of the brain, the left and right sides of the brain gradually form a dominant brain area for a certain function, and the cerebral cortex on different sides has an advantage in a certain function. Memory has an advantage. In addition, the location of fibers within the corpus callosum also affects the function of projections to contrala...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 赵艳黄治中周元国李平宁亚蕾单发波杨楠彭艳熊仁平陈惺
Owner 中国人民解放军陆军特色医学中心
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