Cis-platinum cross-linked protein hydrogel and preparation method thereof

A technology of cross-linking protein and protein water, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas. Degradability, good biocompatibility, easy preparation
CN113995714AActive Publication Date: 2022-02-01HANGZHOU NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HANGZHOU NORMAL UNIVERSITY
Publication Date
2022-02-01

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Abstract

The invention discloses a cis-platinum cross-linked protein hydrogel and a preparation method thereof. The cisplatin cross-linked protein hydrogel is prepared from the following main components in percentage by mass: 0.5 to 5.0 percent of drug, 6.0 to 50.0 percent of serum albumin and 47.0 to 93.0 percent of solvent medium, wherein carboxyl on the surface of the serum albumin and a drug form a coordinate bond; and the drug is cis-platinum. The hydrogel preparation provided by the invention is simple in structure and easy to prepare, and the used cis-platinum has dual effects: the used cis-platinum is a cross-linking agent for promoting the formation of protein hydrogel and is also an anti-tumor drug for playing a tumor inhibition curative effect. Introduction of other components is effectively reduced, and the potential risk of body side effects is reduced; and on the other hand, the protein carboxyl group limits the release of the cis-platinum through the coordination effect, so that the burst release behavior of the medicine can be reduced to a great extent, and the reduction of the toxicity of the cis-platinum in the body tissue is facilitated.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a protein hydrogel with cisplatin as a cross-linking agent and a preparation method thereof. Background technique

[0002] Due to the rapid growth of solid tumor tissue, it causes higher intercellular pressure compared with normal physiological tissue, which makes the effective drug concentration in the tumor area during chemotherapy low; in addition, the tumor microenvironment is very complex, which also affects drug diffusion. One of the important reasons. However, the method of intravenous injection has the disadvantages of large toxic and side effects, low effective drug concentration at the lesion site, and the like. Local tumor therapy has the advantages of concentrated drug concentration, less systemic side effects, and can overcome physiological barriers to drug delivery, so it has received extensive research and attention in recent years.

[0003] ...

Claims

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