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Anti-human periostin monoclonal chimeric antibody and application thereof

A chimeric antibody and monoclonal technology, applied in the fields of application, antibody, anti-animal/human immunoglobulin, etc., can solve problems such as weak effect, low binding ability of human complement components, and inability to exert rational therapeutic effect, and achieve functional significant effect

Pending Publication Date: 2022-02-18
HE EYE HOSPITAL SHENYANG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the efficacy of the antibody itself is not strong, and it cannot exert a rational therapeutic effect
Mouse-derived antibodies usually cannot effectively activate the biological effector function of the human body, have low binding ability to human complement components, and the mediated CDC and ADCC functions are weak

Method used

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  • Anti-human periostin monoclonal chimeric antibody and application thereof
  • Anti-human periostin monoclonal chimeric antibody and application thereof
  • Anti-human periostin monoclonal chimeric antibody and application thereof

Examples

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Embodiment Construction

[0045] The invention provides a periostin monoclonal chimeric antibody and its application. Those skilled in the art can learn from the content of this article and appropriately improve the process parameters to realize it. In particular, it should be pointed out that all similar replacements and modifications are obvious to those skilled in the art, and they are all considered to be included in the present invention. The method and application of the present invention have been described through preferred embodiments, and relevant personnel can obviously make changes or appropriate changes and combinations to the method and application herein without departing from the content, spirit and scope of the present invention to realize and apply the present invention Invent technology.

[0046] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. For definitions and terms in this ...

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PUM

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Abstract

The invention relates to the technical field of antibodies, in particular to an anti-human periostin monoclonal chimeric antibody and application thereof. Three CDR regions of a light chain of the anti-human periostin monoclonal chimeric antibody provided by the invention respectively have amino acid sequences as shown in SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3; the three CDR regions of a heavy chain respectively have amino acid sequences as shown in SEQ ID NO:4, 5 and 6. The heavy chain variable regions and the light chain variable regions are respectively chimeric with a human heavy chain constant region and a human light chain constant region to form an anti-human periostin chimeric antibody which is safer and more reliable and has more remarkable functions compared with an anti-human periostin monoclonal antibody in the prior art, and the chimeric antibody has a high-specificity anti-periostin effect.

Description

technical field [0001] The invention relates to the technical field of antibodies, in particular to an anti-human periostin monoclonal chimeric antibody and its application. Background technique [0002] Periostin consists of 835 amino acids with a molecular weight of 90kDa; protein sequence analysis shows that this periostin contains a typical signal sequence and 4 repeat domains rich in cysteine, and has a C-terminal domain; because the C-terminal domain Alternative splicing is caused by the difference in transcription process, and its transcripts have 4 different monomers, and the expression of each monomer is not the same in different tissues. The study of the biological function of periostin shows that periostin is a cell matrix protein, the expression of periostin is up-regulated during tissue injury and tissue repair, and can be combined with proteins in the extracellular matrix. Periostin is a unique extracellular matrix protein, and its expression is mainly concent...

Claims

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Application Information

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IPC IPC(8): C07K16/18C12N15/13G01N33/68A61K39/395A61P35/00A61P9/00
CPCC07K16/18G01N33/68A61P35/00A61P9/00C07K2317/24C07K2317/56C07K2317/565C07K2317/567C07K2317/92A61K2039/505Y02A50/30
Inventor 李雪娇赵洪礼何伟何向东张朔赵航冯铃刘辉张鹏周艳楠
Owner HE EYE HOSPITAL SHENYANG
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