A kind of traditional Chinese medicine compound thermosensitive gel embolic agent and its preparation method and application

A technology of sensitive gel embolizing agent and traditional Chinese medicine, applied in the field of antitumor preparations, can solve the problems of poor oral absorption, insoluble in water, low bioavailability, etc., and achieve the effects of good fluidity and good MRI visualization function
CN114081990BActive Publication Date: 2022-07-01JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
Publication Date
2022-07-01

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Abstract

The present invention relates to a traditional Chinese medicine composite thermosensitive gel embolic agent, a preparation method and application thereof. α (HIF‑1 α ), a mixed oil phase of tributyrin and ethyl oleate, a surfactant, a co-surfactant and water, and the Chinese medicine polysaccharide composite temperature-sensitive material is N -The hydrogel material obtained by the polymerization of isopropylacrylamide in the traditional Chinese medicine polysaccharide solution. The traditional Chinese medicine compound thermosensitive gel embolizing agent of the present invention can significantly enhance the embolic effect of the embolizing agent on the end of liver cancer blood vessels, promote the thrombus formation at the embolization site, and induce M1-type polarization and HIF-1 of tumor-associated macrophages (TAMs) by inducing α Its expression remodels the tumor immune microenvironment, improves the efficacy of interventional therapy for liver cancer, and reduces the risk of recurrence.
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Description

technical field

[0001] The invention belongs to the field of antitumor preparations, in particular to a traditional Chinese medicine compound thermosensitive gel embolic agent, a preparation method of the thermosensitive gel embolic agent, and an application in the preparation of a liver cancer embolization treatment agent. Background technique

[0002] Transarterial embolization / chemoembolization (TAE / TACE) is the standard clinical treatment for middle-advanced primary liver cancer, which can block tumor blood supply through hepatic artery injection of embolic agents, resulting in ischemic necrosis. At present, TAE / TACE treatment still has the limitations of limited efficacy and easy recurrence. The important reasons are: (1) The existing embolic agents cannot completely block the blood vessels at the end of the tumor, which leads to the generation of collateral circulation and restores blood supply to the tumor site; ②Long-term ischemia and hypoxia at the site of postopera...

Claims

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