Traditional Chinese medicine composite temperature-sensitive gel embolization agent, and preparation method and application thereof

A sensitive gel embolism, traditional Chinese medicine technology, applied in the field of anti-tumor preparations, can solve the problems of poor oral absorption, insoluble in water, low bioavailability, etc., and achieve the effect of good fluidity and good MRI visualization function
CN114081990AActive Publication Date: 2022-02-25JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
Publication Date
2022-02-25

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Abstract

The invention relates to a traditional Chinese medicine composite temperature-sensitive gel embolization agent, and a preparation method and application thereof. The traditional Chinese medicine composite temperature-sensitive gel embolization agent comprises a traditional Chinese medicine polysaccharide composite temperature-sensitive material, superparamagnetic iron oxide nanoparticles, a traditional Chinese medicine component for inhibiting the expression of hypoxia-inducible factor-1 alpha (HIF-1 alpha), a mixed oil phase of triglyceride and ethyl oleate, a surfactant, a cosurfactant and water, wherein the traditional Chinese medicine polysaccharide composite temperature-sensitive material is a hydrogel material obtained by carrying out polymerization reaction on N-isopropylacrylamide in a traditional Chinese medicine polysaccharide solution. The traditional Chinese medicine composite temperature-sensitive gel embolism agent can significantly enhance the liver cancer vascular terminal embolism effect of the embolism agent, promote thrombosis of embolism parts, remodel a tumor immune microenvironment by inducing M1 type polarization of tumor-related macrophages (TAMs) and expression of HIF-1alpha, improve the curative effect of liver cancer interventional therapy and reduce the recurrence risk.
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Description

technical field

[0001] The invention belongs to the field of antitumor preparations, and in particular relates to a traditional Chinese medicine composite temperature-sensitive gel embolic agent, a preparation method of the temperature-sensitive gel embolic agent and an application in preparing an embolism therapeutic agent for liver cancer. Background technique

[0002] Transarterial embolization / chemoembolization (TAE / TACE) is the clinical standard treatment method for advanced primary liver cancer. It can block the tumor blood supply by injecting embolization agents through the hepatic artery, resulting in ischemic necrosis. At present, TAE / TACE treatment still has the limitations of limited curative effect and easy recurrence. The important reasons are: ① The existing embolic agents cannot completely block the blood vessels at the end of the tumor, which will lead to the generation of collateral circulation and regain blood supply to the tumor site; ②Long-term ischemia a...

Claims

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