Organic small molecule dye, J aggregation nanoparticles and preparation method and application of J aggregation nanoparticles

A nanoparticle and small molecule technology, applied in the field of bio-optical diagnosis and treatment, can solve problems such as few reports, and achieve the effect of obvious structural characteristics, improved treatment effect, and wide imaging range.

Active Publication Date: 2022-03-01
NANJING UNIV OF POSTS & TELECOMM
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the current related work on PDT / PTT combined therapy, the excitation light source is still mainly concentrated in the NIR-I region, and there are few reports on the simultaneous generation of two therapeutic effects under NIR-II laser irradiation.

Method used

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  • Organic small molecule dye, J aggregation nanoparticles and preparation method and application of J aggregation nanoparticles
  • Organic small molecule dye, J aggregation nanoparticles and preparation method and application of J aggregation nanoparticles
  • Organic small molecule dye, J aggregation nanoparticles and preparation method and application of J aggregation nanoparticles

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Embodiment Construction

[0034] The present invention will be described in more detail below in conjunction with the accompanying drawings and specific experimental methods. The following examples are only used to illustrate the technical solution of the present invention more clearly, but not to limit the protection scope of the present invention.

[0035] The reagents used in the implementation of the present invention are all commercially available,

[0036] 1. A small organic molecule dye, the structural formula of the dye is:

[0037]

[0038] The synthetic route of described organic small molecule dye is:

[0039]

[0040] Its concrete preparation steps are as follows:

[0041] A. Compound 2 (2.5 g, 5 mmol) was dissolved in 50 mL of anhydrous tetrahydrofuran, the solution was cooled to -78° C., and n-BuLi (5.2 mL, 12.5 mmol, 2.4 M hexane solution) was slowly added under nitrogen protection. Keep stirring the mixed solution at -78°C for 1.5h, then add Bu 3 SnCl (4.1g, 12.5mmol); the rea...

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Abstract

The invention discloses an organic small molecule dye, and discloses a preparation method and application of the dye and J aggregation nanoparticles thereof. The J aggregation nanoparticles are prepared by a nano coprecipitation method based on an organic small molecule dye and an amphiphilic polymer. The nanometer diagnosis and treatment particles with the maximum optical absorption and the maximum fluorescence emission in an NIR-II area are prepared through the unique property of J aggregation, meanwhile, the fluorescence emission wavelength of the nanometer particles can extend to the NIR-IIb area, and the nanometer diagnosis and treatment particles can be applied to high-resolution imaging of living blood vessels and tumors excited by 1064 nm laser. The nanoparticles can generate photo-thermal and photodynamic properties under 1064nm laser irradiation, so that the nanoparticles can be applied to combined treatment of deep tumors, the treatment effect is remarkably improved, and the nanoparticles have good clinical application prospects.

Description

technical field [0001] The invention belongs to the field of bio-optical diagnosis and treatment, and more specifically relates to a small organic molecule dye, J-aggregation nanoparticles and a preparation method and application thereof. Background technique [0002] Fluorescence imaging plays an important role in basic research and clinical applications such as biomedical detection and image-guided surgery. Compared with traditional imaging modalities, such as X-ray computed tomography, positron emission tomography, and magnetic resonance imaging, fluorescence imaging has many advantages such as high spatiotemporal resolution, real-time detection, and low cost. This imaging technique enables visualization at the molecular or cellular level, thereby helping us better understand biological functions or disease mechanisms. However, fluorescence imaging in the past mainly focused on the near-infrared region (NIR-I, 700-900nm), and short-wavelength luminescence has poor penetr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09B57/00C07D495/14C09K11/06A61K9/51A61K41/00A61K49/00A61P35/00B82Y5/00B82Y40/00G01N21/64
CPCC09B57/00C07D495/14C09K11/06A61K41/0057A61K41/0052A61K9/5146A61P35/00A61K49/0021B82Y5/00B82Y40/00G01N21/6428C09K2211/1011C09K2211/1037C09K2211/1092
Inventor 王其刘加伟范曲立许兴鹏
Owner NANJING UNIV OF POSTS & TELECOMM
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