Research method for key genes of intracranial aneurysm formation and rupture

A technique for intracranial aneurysm and key genes, applied in the field of bioinformatics

Pending Publication Date: 2022-03-11
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, few studies identified potential key genes leading to the formation...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Research method for key genes of intracranial aneurysm formation and rupture
  • Research method for key genes of intracranial aneurysm formation and rupture
  • Research method for key genes of intracranial aneurysm formation and rupture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0043] The following description serves to disclose the present invention to enable those skilled in the art to carry out the present invention. The preferred embodiments described below are only examples, and those skilled in the art can devise other obvious variations.

[0044] Such as Figure 1-Figure 15 The research method for the key genes of intracranial aneurysm formation and rupture includes the following steps:

[0045] S1. Chip data acquisition and chip data preprocessing;

[0046] S2. Key gene screening;

[0047] S3. Gene function enrichment analysis and immune microenvironment analysis.

[0048] Step S2 includes any one of differentially expressed gene screening methods, WGCNA methods, and protein interaction network analysis.

[0049] The differentially expressed gene screening method includes using the limma package of the R language to screen differentially expressed genes. The standard for differentially expressed genes is set to be less than 0.05, and the ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the field of bioinformatics, in particular to a research method of key genes of intracranial aneurysm formation and rupture, which comprises the following steps: S1, chip data acquisition and chip data pretreatment; s2, screening key genes; s3, gene function enrichment analysis and immune microenvironment analysis, on the basis of screening of key genes, a method combining differential expression gene analysis and WGCNA is adopted, on the basis, the key genes obtained after intersection of results of the two methods are subjected to protein interaction network analysis, the gene with the most core of IAs formation and rupture is screened out, and the key genes with the core of IAs formation and rupture are screened out. The method realizes identification of potential key genes causing formation and rupture of IAs through a weight gene co-expression network analysis method.

Description

technical field [0001] The invention relates to the field of bioinformatics, in particular to a research method for key genes of intracranial aneurysm formation and rupture. Background technique [0002] The formation of intracranial aneurysms (Intracranial Aneurysms, IAs) is considered to be the result of both genetic and environmental factors. Similarly, there are genetic and environmental factors in the occurrence of IAs rupture. Many studies have discussed the risk factors and pathophysiological mechanisms of IAs formation and rupture. For example, related studies have shown that factors such as immune inflammatory response, extracellular matrix degradation, and hemodynamic stress are involved in the occurrence and rupture of IAs. Although many studies have carried out detailed experiments to elucidate the relevant molecular mechanisms, the exact mechanism affecting the formation and rupture of IAs has not yet been clarified, so the genes and possible molecular mechanis...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): G16B40/00G16B5/00G16B20/00
CPCG16B40/00G16B5/00G16B20/00
Inventor 曹鑫吴一凡耿道颖张军吕锟曾延玮付君言印旭阳韩燕许思亭于泽宽冯喆唐烨潘磊
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap