Peptide with hair growth promoting activity and application thereof

A technology of active ingredients and sequences, applied in the field of peptides with hair growth-promoting activity and its uses, can solve problems such as male sexual dysfunction, achieve the effect of improving hair loss or promoting hair growth, promoting hair growth, preventing or treating hair loss

Active Publication Date: 2022-03-11
CAREGEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in the case of minoxidil, it has been reported as side effects such as weight gain, edema, dermatitis, increased heart rate, and in the case of finasteride, which requires continuous use, and has male sexual dysfunction, The side effects of pregnant women giving birth to deformed children, so there is still a need to develop a hair loss treatment agent without side effects
[0005] In this technological background, various studies on improving hair loss through mechanisms such as hormone control, metabolic control, etc. are underway (Korean Patent Publication No. 2002-0005332), but have not yet been completed

Method used

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  • Peptide with hair growth promoting activity and application thereof
  • Peptide with hair growth promoting activity and application thereof
  • Peptide with hair growth promoting activity and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0070] Example 1: Synthesis of Peptides

[0071]By using an automatic peptide synthesizer (Milligen 9050, Millipore, U.S.), the peptide with the amino acid sequence of SEQ ID NO: 1 shown in Table 1 below was synthesized, and by using C18 reversed-phase high-performance liquid chromatography (HPLC) (Waters Associates, USA) to purify and isolate these synthetic peptides. As a column, ACQUITYUPLC BEH300 C18 (2.1㎜×100㎜, 1.7 μm Waters Co, USA) was used.

[0072] [Table 1]

[0073] amino acid sequence SEQ ID NO: TKVFPQD 1

Embodiment 2

[0074] Example 2: Confirmation of the effect of peptides on promoting the proliferation or activity of hair follicle cells

[0075] 1. Confirm the effect of promoting the proliferation mechanism of dermal papilla cells

[0076] This was to confirm the effect of the peptide consisting of the amino acid sequence of SEQ ID NO: 1 on promoting the proliferation of hair follicle cells. Specifically, human hair follicle dermal papilla cells (Human hair follicle dermal papilla cells) were divided into 4×10 5 The density of cells / well was seeded in 96-well plates and then cultured for 16 hours. After changing to a serum-free medium, the peptides were treated with 0.5 μM, 5 μM or 50 μM concentrations of the peptides, respectively, and cultured for 1 day. As a positive control group, 5 µM of Minoxidil, which is a therapeutic agent for hair loss, was used for treatment. Cells were harvested and nuclei were isolated using a nuclear protein extraction kit (Merck, USA). The factor β-cate...

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Abstract

The present application relates to a peptide having hair growth promoting activity and a use thereof, and provides a peptide consisting of the amino acid sequence of SEQ ID NO: 1, a cosmetic composition for improving hair loss or promoting hair growth comprising the peptide, and a pharmaceutical composition for preventing or treating hair loss comprising the peptide.

Description

technical field [0001] The present application relates to a peptide with hair growth promoting activity and its use. Background technique [0002] As the aging society progresses, more and more people are concerned about hair loss, and it used to be a major problem for middle-aged men, but recently young people and women are also becoming more interested in hair loss prevention and hair maintenance. Meanwhile, hair loss is considered to be a series of aging phenomena, but recent studies have shown that hair loss is due to various reasons, such as genetic factors, stress, Westernization of eating habits, nutritional imbalances, and changes in social activities, etc. [0003] Currently, minoxidil (6-amino-1,2-dihydro-1-hydroxy-2-imino-4-phenoxypyrimidine) (US Patent No. 3,382,247) and finasteride (US Patent No. 5,215,894) is approved by the US FDA as a drug with a hair growth effect. Minoxidil was developed as a vasodilator for the treatment of high blood pressure in the ear...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06A61K8/64A61P17/14A61Q7/00A61K38/00
CPCA61K38/00A61Q7/00C07K7/06A61K8/64A61P17/14Y02P20/55A61K38/04
Inventor 郑镕池金银美李应智金敏雄
Owner CAREGEN
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