Soft tissue reinforced membrane material as well as preparation method and application thereof

A technology for enhancing membrane and soft tissue, applied in the field of medical biomaterials, to achieve the effects of reducing anastomotic leakage and bleeding, easy operation and simple manufacturing process

Pending Publication Date: 2022-03-15
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the deficiencies of the above-mentioned prior art, the present invention provides a soft tissue reinforcement membrane material that can be used together with a linear stapler and its preparation method and application. Too large to prevent technical problems such as anastomotic leakage and anastomotic stenosis

Method used

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  • Soft tissue reinforced membrane material as well as preparation method and application thereof
  • Soft tissue reinforced membrane material as well as preparation method and application thereof
  • Soft tissue reinforced membrane material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The specific technical scheme of the preparation method of the soft tissue reinforcement membrane material provided in this embodiment is as follows:

[0030] Adopt electrospinning method to prepare polymer fiber membrane, its component comprises polyglycolic acid (PGA), and solvent is hexafluoroisopropanol, and concentration is 20%, and preparation method comprises the following steps:

[0031] (1) Mix polyglycolic acid (PGA) and hexafluoroisopropanol at a ratio of 20% by mass to volume, heat and stir at 40°C until dissolved to obtain a solution with a certain viscosity, that is, the spinning solution;

[0032] (2) Cool the solution in step (1) to room temperature, put it into a 10ml injection needle, and use a single-nozzle electrospinning device to spin at room temperature. The inner diameter of the spinneret is 0.4mm, and the receiving distance is 25cm. The speed is 20μl / min, the voltage is 25KV, and the receiving device is a roller to obtain the electrospun membran...

Embodiment 2

[0038] The specific technical scheme of the preparation method of the soft tissue reinforcement membrane material provided in this embodiment is as follows:

[0039] Adopt electrospinning method to prepare polymer fiber membrane, its component comprises polyglycolic acid (PGA), and solvent is hexafluoroisopropanol, and concentration is 20%, and preparation method comprises the following steps:

[0040] (1) Mix polyglycolic acid (PGA) and hexafluoroisopropanol at a ratio of 20% by mass to volume, heat and stir at 40°C until dissolved to obtain a solution with a certain viscosity, that is, the spinning solution;

[0041] (2) Cool the solution in step (1) to room temperature, put it into a 10ml injection needle, and use a single-nozzle electrospinning device to spin at room temperature. The inner diameter of the spinneret is 0.1mm, and the receiving distance is 25cm. The speed is 25μl / min, the voltage is 25KV, and the receiving device is a roller to obtain the electrospun membran...

Embodiment 3

[0045] The specific technical scheme of the preparation method of the soft tissue reinforcement membrane material provided in this embodiment is as follows:

[0046] Adopt electrospinning method to prepare polymer fiber membrane, its component comprises polyglycolic acid (PGA), and solvent is hexafluoroisopropanol, and concentration is 20%, and preparation method comprises the following steps:

[0047] (1) Mix polyglycolic acid (PGA) and hexafluoroisopropanol at a ratio of 20% by mass to volume, heat and stir at 40°C until dissolved to obtain a solution with a certain viscosity, that is, the spinning solution;

[0048](2) Cool the solution in step (1) to room temperature, put it into a 10ml injection needle, and use a single-nozzle electrospinning device to spin at room temperature. The inner diameter of the spinneret is 0.6mm, and the receiving distance is 20cm. The speed is 25μl / min, the voltage is 25KV, and the receiving device is a roller to obtain the electrospun membrane...

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Abstract

The invention belongs to the technical field of medical biological materials, and particularly relates to a soft tissue reinforced membrane material and a preparation method thereof. The preparation method of the soft tissue reinforced membrane material provided by the invention has the advantages that the preparation process is simpler, the operation is easy, the production is easier to change, the raw materials are all biodegradable materials, the raw materials are discharged out of a body along with the metabolism of a human body after postoperative use, and the soft tissue reinforced membrane material has good biological activity and does not have cytotoxicity. The polymer fiber membrane is prepared by adopting an electrostatic spinning technology, has a porous structure, and meets the requirements of cell adhesion growth and serving as a nutrient substance conveying channel. After the soft tissue reinforcing membrane material provided by the invention is implanted into a living body, the conditions of rejection reaction, local injury and the like cannot be generated, and the soft tissue reinforcing membrane material is matched with an anastomat for use, so that the soft tissue can be effectively reinforced, and the morbidity of anastomotic fistula, bleeding and inflammatory reaction is reduced.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, and in particular relates to a soft tissue reinforcement membrane material and a preparation method and application thereof. Background technique [0002] Soft tissue is a very important human tissue, including skin, subcutaneous tissue, muscle, tendon, ligament, joint capsule, synovial bursa, nerve, blood vessel, etc. Most soft tissue injuries in the human body can heal on their own and restore their essential functions. For example, most skin injuries will not leave scar tissue after self-healing; fascia, tendons, ligaments and other connective tissues through self-healing will also restore their corresponding functions. However, if soft tissue damage is caused during the operation, self-healing may not achieve the expected results, resulting in the failure of the operation. For example, in large gastrectomy, due to loose sutures, tissue recovery is slow, resulting in anastomotic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/14D04H1/728D04H1/44D01D5/00
CPCA61L31/06A61L31/14A61L31/146A61L31/148D04H1/728D04H1/44D01D5/003A61L2300/412C08L67/04
Inventor 栗可心郑志国张向东张慧敏杨美平
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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