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Intracranial delivery of pharmaceutical solutions

A solution and catheter technology, used in drug delivery, drug devices, internal fixators, etc., can solve problems such as inability to cross the blood-brain barrier, damage, and descent

Pending Publication Date: 2022-03-18
INCUBE LABS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The side effects of radiation therapy and chemotherapy can therefore be extremely serious, such as damage to important areas of the brain leading to a decline in language, motor skills and cognitive skills
Additionally, many drugs are unable to cross the blood-brain barrier in any meaningful amount

Method used

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  • Intracranial delivery of pharmaceutical solutions
  • Intracranial delivery of pharmaceutical solutions
  • Intracranial delivery of pharmaceutical solutions

Examples

Experimental program
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Embodiment Construction

[0029] Techniques and devices for intracranial drug delivery for the treatment of brain growths and other neurological conditions are described herein. Intracranial drug delivery can be into brain tissue or into the cerebrospinal fluid (CSF) inside the brain (eg, inside the ventricle).

[0030] Before discussing the details of techniques and devices used for intracranial drug delivery, some conventions are provided for the convenience of the reader.

[0031] Various abbreviations are used herein to refer to standard units such as deciliter (dl), milliliter (ml), microliter (μl), international unit (IU), centimeter (cm), millimeter (mm), kilogram (kg), Grams (gm), milligrams (mg), micrograms (μg), millimoles (mM), degrees Celsius (°C), degrees Fahrenheit (°F), millitorr (mTorr), hours (hr), or minutes (min).

[0032] When used in this disclosure, the terms "for example", "such as", "such as", "for example", "for another example", "an example of", "as an example" and "etc. ” i...

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Abstract

Embodiments provide for intracranial delivery of a pharmaceutical solution to the brain. A system includes a borehole occluder for insertion in a cranial borehole, a catheter, a connection member, a connector tube, and a pump. The catheter advances through an opening in the occluder to a tissue site in the brain. The proximal portion of the catheter is secured to the outer channel in the occluder to minimize movement of the catheter in the brain. The catheter, the connection member, the connector tube, and the pump are fluidly coupled together to form a flow path between the pump and the distal end of the catheter for infusion of a pharmaceutical solution to a tissue site in the brain.

Description

[0001] Cross References to Related Applications [0002] This application claims priority and benefit to U.S. Provisional Patent Application No. 62 / 881,875, filed August 1, 2019, and entitled Devices, Systems and Methods for Intracranial Delivery of Therapeutic Agents to Treat Brain Tumors, the U.S. Provisional Patent Application The entire contents are incorporated herein by reference for all purposes. technical field [0003] Embodiments relate to devices, systems and methods for treating adverse neurological conditions, such as devices, systems and methods for treating brain tumors or other cranial growths. Background technique [0004] Brain cancer and other nervous system cancers are the leading causes of death in both men and women. For example, glioblastoma multiforme is the most commonly diagnosed primary brain tumor in adults, with an incidence of 2-3 cases per 100,000 per year. This is a particularly deadly and rapidly acting form of cancer, as the median untreat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61M25/00A61M39/02A61F2/28A61B17/68A61N1/05
CPCA61F2/2875A61F2002/30581A61M2039/0273A61M39/0247A61M2039/2406A61M39/24A61M2205/3584A61M2205/3331A61M5/14276A61M5/14248A61M2005/16863A61M5/1684A61M2205/18A61M5/172A61M2005/1726A61M2205/581A61M2205/583A61M2210/0687A61M2205/32A61M39/0208A61M5/007A61M2205/3576A61M2205/0266A61M2039/025A61M25/007A61M25/0102A61M2039/0205A61M2039/0267A61M2039/027A61M2205/3334A61M2205/3344
Inventor M·伊姆兰M·哈希姆
Owner INCUBE LABS
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