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Treatment and diagnosis of chronic inflammation of lower urinary tract

A chronic inflammatory, chronic technology, applied in disease diagnosis, sexual diseases, anti-inflammatory agents, etc., can solve problems such as lack of treatment methods

Pending Publication Date: 2022-03-22
SELECTIMMUNE PHARM AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] There is currently a lack of specific treatments and options available to patients for pain management, which often include opioids due to the severity of the clinical condition

Method used

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  • Treatment and diagnosis of chronic inflammation of lower urinary tract
  • Treatment and diagnosis of chronic inflammation of lower urinary tract
  • Treatment and diagnosis of chronic inflammation of lower urinary tract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0130] Example 1: IL1 inhibitors for the treatment of CPPS

[0131] The present teachings relate to the treatment of pain and pain-related symptoms of chronic pelvic pain syndrome, wherein the method comprises administering an IL1 inhibitor to a subject in need thereof.

[0132] The present teachings also relate to relief of pain and pain-related symptoms of chronic pelvic pain syndrome, wherein the method comprises administering an IL1 inhibitor to a subject in need thereof.

[0133] The present teachings also relate to a method of reducing pain and pain-related symptoms of chronic pelvic pain syndrome, wherein the method comprises administering an IL1 inhibitor to a subject in need thereof.

[0134]According to a specific embodiment, an IL-1 inhibitor (eg, an IL-1 receptor antagonist) is used in a method of treating, alleviating or alleviating pain and pain-related symptoms of chronic pelvic pain syndrome. The chronic pelvic pain syndrome may be a urologic pain syndrome, an...

Embodiment 2

[0146] Example 2: Anakinra for Chronic Inflammatory Conditions

[0147] Applicants performed an open-label trial of anakinra in patients with chronic inflammatory diseases of the lower urinary tract, specifically chronic cystitis and CPPS. This structured observational study aimed to investigate the effects of anakinra in the treatment of patients with chronic cystitis and CPPS.

[0148] Patient Visit Overview

[0149] Inclusion visit: Patients were informed about the study and were included in the study after obtaining signed informed consent. Conduct structured interviews and clinical surveys. Disease severity was assessed using a symptom score. A follow-up appointment was made.

[0150] Samples: blood and urine samples for investigation of inflammatory processes and for genetic and proteomic analysis.

[0151] Visit 1:

[0152] Conduct structured interviews and clinical surveys. Record symptom severity.

[0153] Initiate treatment with anakinra and continue for se...

Embodiment 3

[0229] Example 3: Treatment of BPS

[0230] Painful bladder syndrome (BPS) can disrupt professional, social life, and sexual health as patients experience debilitating pain, extremely frequent urination, and a sense of urgency. Many treatments have been tested, but with the exception of antibiotics for superinfections or painkillers, treatment has had limited success and patients are often severely disabled. The molecular basis of BPS remains a mystery, hindering the development of more specific therapeutic options.

[0231] By analyzing the inflammatory phenotype of acute cystitis, IL-1 was recently identified as a cause of acute bladder pathology, exacerbated by genetic susceptibility affecting the inflammatory components Asc and Nlrp3. In a mouse cystitis model (ref), the IL-1 receptor antagonist Kineret (anakinra) significantly reduced bladder inflammation and increased bacterial clearance. IL-1R blockade also affects the pain receptor NK1R in the bladder mucosa, linking...

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Abstract

There is provided a method of treating a chronic inflammatory condition of the lower urinary tract, the method comprising administering to a patient in need thereof an effective amount of a formulation selected from the group consisting of an IL-1 [beta] inhibitor and an MMP inhibitor, or a protein selected from the group consisting of ASC or NLRP-3. Diagnostic methods are also described and claimed. The present invention also relates to an IL-1 inhibitor for use in a method of treating, alleviating or alleviating pain and pain-related symptoms of chronic pelvic pain syndrome. The IL-1 inhibitor may be an IL-1 receptor antagonist. The IL-1 inhibitor can be analectin. The IL-1 inhibitor can be analectin. The chronic pelvic pain syndrome may be urinary system pain syndrome, external genital gynecological pain syndrome, internal pelvic pain syndrome, and gastrointestinal pelvic pain syndrome.

Description

technical field [0001] The present invention relates to methods of treating chronic inflammatory states of the lower urinary tract and chronic pain, compositions useful in these treatments, and diagnostic methods related thereto. In particular, the present invention relates to an IL-1 inhibitor for use in a method of treating, alleviating or alleviating pain and pain-related symptoms of chronic pelvic pain syndrome. Background technique [0002] Chronic inflammation affects the bladder and lower abdomen. Bladder pain is usually caused by an acute infection, but in some individuals, chronic pain can persist without infection. Therefore, antibiotic therapy is not particularly helpful in treating such diseases. Chronic cystitis (also known as interstitial cystitis (IC), bladder pain, or bladder pain syndrome) may be associated with epithelial erosions or chronic pain without overt systemic inflammation. Chronic cystitis and bladder pain can be a separate disease or part of a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K38/20A61K31/381A61P13/02A61P29/00A61P13/10A61P15/00A61P13/08C12Q1/6883G01N33/68
CPCA61K45/00A61K38/2006A61K31/381A61P13/02A61P29/00A61P13/10A61P15/00A61P13/08C12Q1/6883G01N33/6869G01N33/6893C12Q2600/156G01N2333/545G01N2800/34G01N2800/361G01N2800/364G01N33/9406
Inventor 凯瑟琳娜·斯文堡比约恩·沃尔特丹尼尔·布特勒伊内斯·安比特
Owner SELECTIMMUNE PHARM AB
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