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Solid preparation for treating migraine and preparation method thereof

A technology for solid preparations and migraines, applied in the field of solid preparations for treating migraines and its preparation, can solve the problems of fat-soluble ingredients, large loss of active ingredients, long production cycle, etc., and achieve enhanced blood circulation and menstruation, precise compatibility, Simple operation effect

Pending Publication Date: 2022-03-29
SHANGHAI KAIBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in addition to the active ingredients, the water extract also contains a large amount of impurities, and the decoction is prone to mildew and deterioration and there are fat-soluble ingredients, which brings disadvantages to the refining; the water-alcohol method has a large loss of active ingredients, which affects the curative effect, and the cost is high. The cycle is long, the follow-up processing is difficult, and the characteristics of the traditional Chinese medicine compound water extract are lost
Or a variety of traditional Chinese medicines can be mixed and extracted, but due to the different properties of traditional Chinese medicines, the efficiency of mixing and extracting a variety of Chinese medicines is low, and the active ingredients in Chinese medicines cannot be used to the greatest extent.

Method used

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  • Solid preparation for treating migraine and preparation method thereof
  • Solid preparation for treating migraine and preparation method thereof
  • Solid preparation for treating migraine and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0026] The present embodiment provides a method for preparing a solid preparation for treating migraine, comprising the following steps:

[0027] Step 1: remove impurities, wash and dry Rhizoma Chuanxiong, Angelica dahurica, and Evodia rutaecarpa, and then crush them into fine powder for later use; wash the mint leaves with clean water, crush the mint leaves with a pulverizer and process them into a paste for later use ;

[0028] Step 2: seal the fine powder of Angelica dahurica and water in an extraction container and carry out hydrothermal extraction at 105°C, the extraction time is 1 hour, separate the obtained extract from solid and liquid, and concentrate under reduced pressure to obtain the extract concentrate of Angelica dahurica ; The mass ratio of described Angelica dahurica powder and water is 1:10;

[0029] Step 3, adding 10 times the volume of Chuanxiong fine powder and Evodia rutaecarpa into ethanol with a volume concentration of 80%, extracting twice, each time ...

Embodiment 2

[0035] The present embodiment provides a method for preparing a solid preparation for treating migraine, comprising the following steps:

[0036] Step 1: remove impurities, wash and dry Rhizoma Chuanxiong, Angelica dahurica, and Evodia rutaecarpa, and then crush them into fine powder for later use; wash the mint leaves with clean water, crush the mint leaves with a pulverizer and process them into a paste for later use ;

[0037] Step 2: seal the fine powder of Angelica dahurica and water in an extraction container and carry out hydrothermal extraction at 120°C, the extraction time is 0.5h, separate the obtained extract from solid and liquid, concentrate under reduced pressure, and obtain the extraction and concentration of Angelica dahurica Liquid; The mass ratio of described Angelica dahurica powder and water is 1:15;

[0038] Step 3, adding 5 times the volume of Chuanxiong fine powder and Evodia rutaecarpa into ethanol with a volume concentration of 80%, extracting twice f...

Embodiment 3

[0044] The present embodiment provides a method for preparing a solid preparation for treating migraine, comprising the following steps:

[0045] Step 1: remove impurities, wash and dry Rhizoma Chuanxiong, Angelica dahurica, and Evodia rutaecarpa, and then crush them into fine powder for later use; wash the mint leaves with clean water, crush the mint leaves with a pulverizer and process them into a paste for later use ;

[0046] Step 2: seal the fine powder of Angelica dahurica and water in an extraction container and carry out hydrothermal extraction at 110°C for 0.8 hours, separate the obtained extract from solid and liquid, and concentrate it under reduced pressure to obtain the extraction and concentration of Angelica dahurica Liquid; The mass ratio of described Angelica dahurica powder and water is 1:12;

[0047] Step 3, adding 8 times the volume of Chuanxiong fine powder and Evodia rutaecarpa into ethanol with a volume concentration of 80%, extracting 3 times, each tim...

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Abstract

The invention discloses a solid preparation for treating migraine and a preparation method thereof. The solid preparation is prepared from the following raw materials in parts by weight: 280-320 parts of ligusticum wallichii, 320-350 parts of radix angelicae, 100-120 parts of fructus evodiae and 10-20 parts of mint. According to the preparation method disclosed by the invention, different extraction methods are adopted aiming at the characteristics of each traditional Chinese medicine component, and on the premise of extracting the effective components of the traditional Chinese medicine to the maximum extent, the operation is simple, the cost is saved and the extract quality is improved. In addition, the traditional Chinese medicine composition is rigorous in formula and precise and appropriate in compatibility, and can promote blood circulation and dispel wind. The radix angelicae dahuricae dispels wind, dredges orifices and relieves pain, and is used for treating headache, so that the blood and wind are removed, and the pain is automatically relieved. The traditional Chinese medicine is compatible with fructus evodiae, is hard to use, is pungent and bitter, has the functions of promoting blood circulation and stimulating menstrual flow, can lower the temperature and warm the middle to arrest vomiting, and is actually used for treating migraine. The peppermint is pungent in taste and cool in nature, and is combined with warm medicines, so that the effects of the ligusticum wallichii and the radix angelicae on activating meridians and relieving pain can be improved, and yin injury caused by excessive heat dissipation of the ligusticum wallichii and the radix angelicae can be prevented, and the peppermint and the warm medicines are used together.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a solid preparation for treating migraine and a preparation method thereof. Background technique [0002] Migraine (migraine) is the most common type of primary headache in clinical practice. The main clinical manifestation is paroxysmal moderate to severe, throbbing headache. The headache is mostly hemilateral and usually lasts for 4-72 hours. Light, sound stimulation or daily activities can aggravate the headache, and a quiet environment and rest can relieve the headache. In 1983, the annual incidence of migraine in six major cities in my country was 20.2 / 100,000, and the prevalence rate was 523.9 / 100,000. According to WHO, severe migraine ranks among the top 20 most common medical diseases that make people incapacitated. [0003] The "Huangdi Neijing" says: "The camper is the essence of the water and valley,... the guard is the fierce energy of the water and the va...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/20A61K36/754A61P25/06
CPCA61K9/1652A61K9/205A61K36/236A61K36/232A61K36/754A61K36/534A61P25/06A61K2236/13A61K2236/17A61K2236/15A61K2236/331A61K2236/53A61K2236/51A61K2236/333A61K2236/39A61K2236/19A61K2300/00
Inventor 张小利穆竟伟刘绍勇杜学航
Owner SHANGHAI KAIBAO PHARMA