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Application of emodin in relieving acute hypoxia-induced fish cell apoptosis

A technology of hypoxia induction and emodin, applied in the field of fish cell apoptosis feed, to achieve the effect of enhancing autophagy, reducing cell apoptosis, and inhibiting the level of p-mTOR

Pending Publication Date: 2022-04-01
INST OF AQUATIC LIFE ACAD SINICA
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Currently, there are few studies on the effect of emodin EMO on fish resistance to hypoxic stress in aquaculture

Method used

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  • Application of emodin in relieving acute hypoxia-induced fish cell apoptosis
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  • Application of emodin in relieving acute hypoxia-induced fish cell apoptosis

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Embodiment Construction

[0035] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0036] Here, it should also be noted that, in order to avoid obscuring the present invention due to unnecessary details, only the structures and / or processing steps closely related to the solution of the present invention are shown in the drawings, and the steps related to the present invention are omitted. Invent other details that don't really matter.

[0037] Additionally, it should be noted that the term "comprises", "comprises" or any other variation thereof is intended to cover a non-exclusive inclusion such that a process, method, article or apparatus comprising a set of elements includes not only those elements, but also Other elements not expressly listed, or inherent to the process, method, article, or apparatus are also included.

[00...

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Abstract

The invention provides an application of emodin in relieving acute hypoxia-induced fish cell apoptosis. The emodin enhances autophagy of fish cells by mediating an AMPK / mTOR signal channel of fish, so that apoptosis of the fish cells is inhibited, and damage caused by acute hypoxia conditions to the fish is relieved. The invention also provides a feed for relieving acute hypoxia-induced fish cell apoptosis. The feed comprises a basal feed and a feed additive emodin for relieving acute hypoxia-induced fish cell apoptosis, the feed additive emodin alleviates the damage of acute hypoxia to fish by mediating AMPK / mTOR. The fishes are aquatic freshwater economic fishes.

Description

technical field [0001] The invention relates to the technical field of emodin application, in particular to the application of emodin in alleviating the apoptosis of fish cells induced by acute hypoxia and the feed for alleviating the apoptosis of fish cells induced by acute hypoxia. Background technique [0002] Dissolved oxygen (DO) is one of the key environmental variables for the survival of aquatic fish and is easily affected by natural and man-made environmental changes, such as high temperature, eutrophication of water bodies, industrial wastewater discharge, and high-density aquaculture. In water bodies, one of the most important manifestations of substandard or deteriorating water quality is changes in dissolved oxygen levels, as low levels of dissolved oxygen often result in the death of large numbers of aquatic animals. Environmental hypoxic stress affects the behavior, growth, reproduction and survival of aquatic animals, which has serious negative effects on the...

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Application Information

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IPC IPC(8): A61K31/122A61P39/00A23K20/111A23K50/80
Inventor 金俊琰巫丽云解绶启韩冬朱晓鸣
Owner INST OF AQUATIC LIFE ACAD SINICA
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