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Prevention and treatment of hypoglycemia

A technology for hypoglycemia and serum, applied in metabolic diseases, peptide/protein components, drug combinations, etc., can solve problems such as weakening counter-regulatory responses and hypoglycemia risk

Pending Publication Date: 2022-04-01
DIAMYD MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These studies suggest that increased GABAergic signaling may be associated with attenuated counterregulatory responses and risk of hypoglycemia

Method used

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  • Prevention and treatment of hypoglycemia
  • Prevention and treatment of hypoglycemia
  • Prevention and treatment of hypoglycemia

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Embodiment Construction

[0038] A study was initiated under study protocol 1 below under the study name Regenerate-1 (EudraCT number: 2018-001115-73).

[0039] Unexpectedly, it has been found that GABA can reduce the pathologically increased circulating glucagon concentrations present in type 1 diabetic individuals to more normal concentrations. In view of suggestions in the prior art, as suggested (but not shown in WO2019 / 114718) that GABA acutely increases circulating glucagon levels by acting on glutamate receptors, GABA lowers glucagon levels to normal This ability was unexpected.

[0040] Glucagon concentrations are often pathologically increased in individuals with type 1 and type 2 diabetes, so these individuals have little or no ability to further increase glucagon in response to hypoglycemia. It is important to address this defect in counter-regulatory hormone responses (hormones that increase blood sugar) to protect these patients from severe hypoglycemia. The present invention aims to pro...

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Abstract

The present invention relates to gamma-aminobutyric acid, optionally in combination with a GABA receptor positive allosteric modulator, for use in a method of preventing or reducing the risk of hypoglycemia in a subject.

Description

technical field [0001] The present invention relates to methods of preventing hypoglycemia, reducing the risk of hypoglycemia, and treating impaired counterregulatory responses to hypoglycemia, and compounds useful in such treatment. Background technique [0002] In healthy individuals, hypoglycemia is effectively combated by a cascade of hormones, including inhibition of insulin release, activation of fast-acting glucagon and epinephrine followed by release of slow-acting growth hormone and cortisol. This hormonal response (response) acts to increase glucose production and decrease peripheral glucose utilization, thereby increasing glucose delivery to the brain. [0003] In type 1 diabetes and to some extent in type 2 diabetes, the counterregulatory response is impaired due to three main factors: 1) inability to clear insulin from the system, 2) reduced or absent glucagon release, and 3) Autonomic responses to hypoglycemia are reduced. It has further been shown that patie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/197A61P3/08A61P5/48
CPCA61P3/08A61K31/197A61P5/48A61K45/06A61K31/5517A61K31/5685A61K38/28A61K2300/00A61K31/64
Inventor 丹尼尔·埃斯普佩尔-奥拉·卡尔松
Owner DIAMYD MEDICAL