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Traditional Chinese medicine compound medicine for treating early cirrhosis

A technology of medicine and traditional Chinese medicine, which is applied in the field of pharmaceutical composition and its preparation for the treatment of early liver cirrhosis, which can solve the problems of lack of treatment specificity, prone to liver and kidney, and poor curative effect, so as to improve liver damage and reduce liver collagen deposition Degree, effect of prevention and treatment of early liver cirrhosis

Pending Publication Date: 2022-04-05
上海邦肽生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The main purpose of the present invention is to provide a natural and safe medicine for the treatment of early liver cirrhosis with definite curative effect, few side effects, and to solve the common medicines in the prior art that are prone to liver and kidney toxicity, poor curative effect, and lack of treatment specificity. question

Method used

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  • Traditional Chinese medicine compound medicine for treating early cirrhosis
  • Traditional Chinese medicine compound medicine for treating early cirrhosis
  • Traditional Chinese medicine compound medicine for treating early cirrhosis

Examples

Experimental program
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Effect test

preparation Embodiment 1

[0107] Take 5g of Chinese medicinal materials astragalus, 10g of angelica, 20g of safflower, 35g of spatholobus and 40g of gentian, and decoct them in water for 2 times. 10 times the mass of the medicinal materials), the second decoction water quality is 0.88kg (8 times the total medicinal material quality), the two decoction liquids are combined, concentrated into a concentrated solution, and dried at a temperature of 60°C to obtain the composition 1. A pharmaceutical composition.

preparation Embodiment 2

[0109] Take 10g of Chinese herbal medicines Astragalus, 20g of Angelica, 40g of Safflower, 25g of Caulis Spatholobus and 35g of Gentiana, decoct in water for 2 times, each time from boiling for 1 hour, the quality of water for the first decoction is 1.3kg (for the total 10 times the quality of medicinal materials), the second decoction water quality is 1.04kg (8 times the total medicinal material quality), the two decoction liquids are combined, concentrated into a concentrated solution, and dried at a temperature of 60 ° C to obtain the composition 2 pharmaceutical compositions.

preparation Embodiment 3

[0111] Take 15g of Chinese medicinal materials astragalus, 30g of angelica, 15g of safflower, 15g of spatholobus and 30g of gentian, and decoct them in water for 2 times. 10 times the quality of the medicinal materials), the second decoction water quality is 0.84kg (8 times the total medicinal material quality), the two decoction liquids are combined, concentrated into a concentrated solution, and dried at a temperature of 60°C to obtain the composition 3 pharmaceutical compositions.

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Abstract

The invention discloses a pharmaceutical composition for treating early cirrhosis, the pharmaceutical composition comprises astragalus membranaceus, angelica sinensis, safflower carthamus, caulis spatholobi and felwort, the weight ratio of astragalus membranaceus to angelica sinensis to safflower carthamus to caulis spatholobi to felwort is (1-5): (1-2): (1-2): (1-8): (1-4), the preparation method of the pharmaceutical composition is simple, and the pharmaceutical composition can be used for treating early cirrhosis rats and mice. The traditional Chinese medicine composition can reduce the activity of serum transaminase, increase the level of serum albumin, relieve the degree of liver collagen deposition and improve liver injury and pathological changes of early cirrhosis, and has the effects of preventing and treating early cirrhosis lesions.

Description

technical field [0001] The application belongs to the field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for treating early liver cirrhosis and its preparation method and application. Background technique [0002] Liver cirrhosis is the end stage of most chronic liver diseases. There are extensive liver cell necrosis, nodular regeneration of residual liver cells, connective tissue hyperplasia and formation of fibrous septa in liver histopathology, leading to structural damage of liver lobules and formation of pseudolobules. Gradually deform, harden and develop into liver cirrhosis. In my country, liver cirrhosis is mainly evolved from chronic viral (type B, type C) hepatitis, steatohepatitis, cholestatic hepatitis, and toxic hepatitis. In the early stage of liver cirrhosis, there may be no obvious symptoms due to the strong compensatory function of the liver. In the later stage, obvious liver function damage and portal hypertens...

Claims

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Application Information

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IPC IPC(8): A61K36/515A61P1/16
Inventor 张岩王帆李玉琴
Owner 上海邦肽生物科技有限公司
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