Application of kushenone in preparation of medicine for preventing and treating Parkinson's disease

A technology for Parkinson's disease and matrine, applied in the field of application of matrine in the preparation of drugs for preventing and treating Parkinson's disease

Pending Publication Date: 2022-04-12
DALIAN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report about the use of matrine in the treatment of PD.

Method used

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  • Application of kushenone in preparation of medicine for preventing and treating Parkinson's disease
  • Application of kushenone in preparation of medicine for preventing and treating Parkinson's disease
  • Application of kushenone in preparation of medicine for preventing and treating Parkinson's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Experiment of kurarinone blocking MPTP-induced Parkinson's pathological process by inhibiting soluble epoxide hydrolase (sEH)

[0037] (1) Experimental materials

[0038] Clean-grade male C57BL / 6 mice (23-25 ​​g, 8 weeks old) are commercially available. The room temperature is 22-24°C, the relative humidity is 50%-60%, well ventilated, artificial day and night (12h / 12h), free to eat and drink.

[0039] The kurarinone used in this experiment was isolated from the traditional Chinese medicine Sophora flavescens by the inventor, and was identified as kurarinone by NMR technology. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (abbreviation: MPTP) can also use commercially available matrine.

[0040] (2) Experimental method

[0041] 1) Preparation of MPTP Parkinson's disease mouse model

[0042] Male C57BL / 6 mice were randomly divided into: normal control group, blank administration group (matrine, 20mg / kg / day, dissolved in 10% hydroxypropyl-β-cyclodextrin a...

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Abstract

The invention discloses application of kurarinone in preparation of a medicine for preventing and treating Parkinson's disease, after 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride (MPTP) is adopted for modeling, the athletic ability of a PD mouse is reduced, the levels of dopamine (DA) and metabolites 3, 4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the brain are reduced, and the level of tyrosine hydroxylase (TH) is reduced. Kurarinone is given to inhibit the activity of soluble epoxide hydrolase (sEH) and improve the content of dopamine (DA) and metabolites of 3, 4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the brain, so that MPTP induced PD is improved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of matrine in the preparation of drugs for preventing and treating Parkinson's disease. Background technique [0002] Parkinson's disease (PD) is a neurodegenerative disease that is common in middle-aged and elderly people over 60 years old. Clinically, it is characterized by motor symptoms such as slowness of movement and resting tremor; it is accompanied by non-motor symptoms such as hyposmia, sleep disturbance, and cognitive impairment. Related studies have shown that the degeneration and death of dopamine (Dopamine, DA) neurons in the substantia nigra and the significant reduction of DA content in the striatum are the more prominent pathological changes in Parkinson's disease. In addition, genetic factors, environmental factors, inflammation, oxidative stress, etc. can all lead to the occurrence of Parkinson's disease. The prevalence of PD is as high as 1% among peop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61P25/16
Inventor 孙成鹏马骁驰霍晓奎宁静赵文宇王超田象阁
Owner DALIAN MEDICAL UNIVERSITY
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