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Application of Maca water extract in relieving movement disorder caused by ethyl alcohol

A technology for water extract and movement disorder, which is applied to the application field of maca water extract in relieving alcohol-induced movement disorder, can solve the problems such as the unreported anti-alcoholic effect of maca, anti-alcoholic neurotoxicity and the like, and achieves reproduction. Fast speed, simple processing method, avoid residual effect

Inactive Publication Date: 2018-08-14
HUNAN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on Maca's anti-alcoholic effect and the role of anti-alcohol neurotoxicity.

Method used

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  • Application of Maca water extract in relieving movement disorder caused by ethyl alcohol
  • Application of Maca water extract in relieving movement disorder caused by ethyl alcohol
  • Application of Maca water extract in relieving movement disorder caused by ethyl alcohol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Establishment of Caenorhabditis elegans Drunk Model

[0026] Wild-type Caenorhabditis elegans (N 2 ) as the basis for model establishment, the synchronization and basal culture of Caenorhabditis elegans were carried out with reference to the liquid culture method in the reference (Stiernagle T. Maintenance of C. elegans [J]. Wormbook, 2006: 1-11.). Caenorhabditis elegans feeds on concentrated OP50 with a concentration of 100mg / ml in the bacterial solution, and the concentration of the worm solution is controlled at 2000-2500 worms / mL. At this time, when Caenorhabditis elegans was detected, the head swing frequency was 50-100 times / 30s, and the swallowing movement was 50-90 times / 30s. of alcohol. The average fluorescence intensity of α-synuclein (α-synuclein is an important characteristic protein in the degeneration of dopamine neurons, the NL5901 transgenic strain is used, and the yellow fluorescent label α-synuclein) is set to 1, and the dopamine The avera...

Embodiment 2

[0028] Example 2 Application of maca water extract in alcohol-induced dyskinesia

[0029] Preparation of maca water extract: take dried maca, grind it into powder, use water to extract twice with water with a solid-liquid ratio of 1g:10ml, filter, and combine the two filtrates; then turn to rotary Concentrate the filtrate in a vacuum concentrator, place the concentrated solution in a glass dish and seal it, freeze it at -80°C for at least 2 hours, take it out quickly, and freeze-dry it into powder.

[0030] Dosing method of maca water extract: Dissolve maca water extract powder completely in water, and sterilize it through a 0.22 micron filter membrane, and then add it to the above-mentioned drunken model at a volume final concentration of 5-30 mg / ml to intervene 24h.

[0031]Set up a blank group (worm solution + water), a control group (worm solution + alcohol solution), a drug group (worm solution + alcohol solution + drug solution), and detect the head shaking frequency, s...

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Abstract

The invention relates to application of a Maca water extract in relieving a movement disorder caused by ethyl alcohol. With wild-type caenorhabditis elegans as a modeling basis, a drunkenness model isestablished, elegans in the drunkenness model reflects the obvious movement disorder, conduction of a dopamine neurotransmitter is related to elegans movement, and therefore by measuring the expression condition of alpha-synuclein in the movement disorder caused by ethyl alcohol and the expression quantity of dopaminergic neurons, influence of medicine in the movement disorder caused by ethyl alcohol on the dopaminergic neurons can be reflected. When an aqueous solution of the Maca water extract with the final volume concentration of 5-15 mg / ml is added to the drunkenness model, the average fluorescence intensity of alpha-synuclein of elegans is greatly improved, few aggregation conditions occur, the average fluorescence intensity of the dopaminergic neurons is greatly improved, and the outline is clear; it is proved that the Maca water extract can effectively relieve the movement disorder caused by ethyl alcohol, have the protection effect on the dopaminergic neurons related to movement and reduce damage to the dopaminergic neurons.

Description

technical field [0001] The invention relates to the application of maca water extract in alleviating alcohol-induced movement disorders, in particular to the application of maca water extract in alleviating alcohol-induced movement disorders based on the drunk model of wild-type Caenorhabditis elegans. Background technique [0002] Chinese traditional etiquette is to treat guests with wine. Gradually, alcohol has become an indispensable part of social life, but long-term heavy drinking can have serious effects on the body. For example, neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Because alcohol is one of the pure energy foods, it can be decomposed in the body to produce energy, but it does not contain any nutrients. Excessive drinking will limit the intake of other nutrients, resulting in the lack of various nutrients, and indirectly lead to various nervous system injuries. At the same time, excessive drinking, if the ability to decompos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/31A61P25/14A61P25/00
CPCA61K36/31A61K2236/331A61P25/00A61P25/14
Inventor 李宗军吴中琴李珂戴奕杰
Owner HUNAN AGRICULTURAL UNIV
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