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Application of combined STAT signal channel related gene in colorectal cancer prognosis model

A signal pathway, colorectal cancer technology, applied in the field of tumor molecular biology, can solve the problems of unknown role of regulators and effectors, and achieve high accuracy results

Pending Publication Date: 2022-04-12
GUANGDONG GENERAL HOSPITAL
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

The role of STATs in most cancer types has been studied, but the role of STAT signaling pathways, including their regulators and effectors, in colorectal cancer remains largely unknown

Method used

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  • Application of combined STAT signal channel related gene in colorectal cancer prognosis model
  • Application of combined STAT signal channel related gene in colorectal cancer prognosis model
  • Application of combined STAT signal channel related gene in colorectal cancer prognosis model

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Embodiment Construction

[0060] The above-described objects, features, and advantages of the present invention will be more clearly understood, and the invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be noted that the features of the present application and the features of the present application can be combined with each other in the case of an unable conflict.

[0061] Many specific details are set forth in the following description to facilitate appreciation of the present invention, but the present invention may also employ other different fails thereof, and therefore, the scope of the present invention is not limited to the specific examples disclosed below. The limitations of embodiments.

[0062] method

[0063] 1) Data collection

[0064] Clinical data and gene expression data for colorectal cancer were obtained from the Cancer Genome Structure (TCGA) database and gene expression integration (GEO) database.

[0065] 2) Id...

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Abstract

The invention provides an application of a combined STAT signal channel related gene in a colorectal cancer prognosis model. The combined STAT signal channel related gene is CAV1, EPO, IL13, LEP and NEUROD1. The establishment method of the colorectal cancer prognosis model comprises the following steps: (1) collecting and sorting data; (2) screening differentially expressed STAT signal pathway related genes; (3) constructing a prognosis model of the STAT signal pathway related genes; and (4) constructing a column diagram. The prognosis model has the advantage of high accuracy, can clinically provide a new method for disease diagnosis and prognosis for colorectal cancer patients, reveals the prediction effect of the prognosis model on tumor microenvironment, and provides important information for the development of targeted therapy.

Description

Technical field [0001] The present invention belongs to the field of tumor molecular biology, and is specifically related to the application of a combined STAT signaling pathway associated gene in a prognostic model of colorectal carcinoma. Background technique [0002] In 2020, the colorectal cancer (CRC) was listed as the third largest malignant tumor in the world. The annual new cases have more than 1.9 million cases, more than 900,000 deaths have seriously threatened human health. In the past decade, the rapid development of treatment technology provides hopes for CRC treatment. Targeting treatment is a new choice by giving a genomics, transcriptional, proteomics, and apparent genomics, targeted therapy is becoming a new choice, but is still in its starting phase compared to conventional treatment. Therefore, inventors need new markers and predictive models to assess the prognosis of patients. [0003] In tumor cells and microenvironments, signal transduction and transcriptio...

Claims

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Application Information

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IPC IPC(8): G16H50/30G16B25/10G06F17/18
Inventor 陈浩曾瑞杰沙卫红吴慧欢蒋锐卓泽伟
Owner GUANGDONG GENERAL HOSPITAL
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