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Prognosis model of metabolism-related endometrial cancer and construction method

A technology of endometrial cancer and construction method, which is applied in the field of prognosis model and construction of metabolism-related endometrial cancer, can solve the problems of poor prediction ability and inaccurate results of prognosis indicators of endometrial cancer, and achieve good prediction ability Effect

Pending Publication Date: 2022-04-15
TIANJIN TUMOR HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] One aspect of the present invention is aimed at the disadvantages of poor prediction ability and inaccurate results of endometrial cancer prognosis indicators in the prior art, and provides a prognosis model and construction method of metabolism-related endometrial cancer

Method used

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  • Prognosis model of metabolism-related endometrial cancer and construction method
  • Prognosis model of metabolism-related endometrial cancer and construction method
  • Prognosis model of metabolism-related endometrial cancer and construction method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The flow chart of the construction method is as follows figure 1 shown in A.

[0054] 1. Population inclusion and data download

[0055] In the Cancer Genome Atlas (TCGA) database (https: / / portal.gdc.cancer.gov / ), the expression data and relevant clinical information of the tumor samples and normal sample tissue transcriptomes of patients with endometrial cancer (UCEC) were retrieved. The retrieval time of this study was set from the establishment of the TCGA database to December 10, 2021. Inclusion criteria Stage I-IV endometrial cancer (including adenoma, cystic adenocarcinoma, mucinous tumor, serous tumor and epithelial tumor) with follow-up time and complete clinical data, selected 575 UCEC patients who finally met the inclusion criteria of this study The samples were the research objects, including 552 cases of tumor samples and 23 cases of normal samples.

[0056] 2. Collection of metabolism-related targets

[0057] In the human gene set database GSEA (http: / / ...

Embodiment 2

[0073] The flow chart of the construction method is as follows figure 1 shown in B.

[0074] 1. Population inclusion and data download

[0075] In the Cancer Genome Atlas (TCGA) database (https: / / portal.gdc.cancer.gov / ), the expression data and relevant clinical information of the tumor samples and normal sample tissue transcriptomes of patients with endometrial cancer (UCEC) were retrieved. The retrieval time of this study was set from the establishment of the TCGA database to December 10, 2021. Inclusion criteria Stage I-IV endometrial cancer (including adenoma, cystic adenocarcinoma, mucinous tumor, serous tumor and epithelial tumor) with follow-up time and complete clinical data, selected 575 UCEC patients who finally met the inclusion criteria of this study The samples were the research objects, including 552 cases of tumor samples and 23 cases of normal samples.

[0076] 2. Collection of metabolism-related targets

[0077] In the human gene set database GSEA (http: / / ...

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Abstract

The invention discloses a construction method of a metabolism-related endometrial cancer (UCEC) prognosis model. According to the construction method, differential genes are screened out layer by layer by using transcriptome data of UCEC in a public database TCGA to construct a prognosis model of metabolism-related UCEC, and it is verified that the prognosis model has good predictive capacity for endometrial cancer patients. The prognosis model can be used for guiding clinical endometrial cancer molecular typing and individualized treatment strategies, and products related to endometrial cancer diagnosis, treatment and prognosis can be further developed according to the core gene in the prognosis model.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a prognosis model and a construction method of metabolism-related endometrial cancer. Background technique [0002] Endometrial cancer (UCEC) is an epithelial malignant tumor that originates in the endometrium. It ranks third in the middle, next to breast cancer and lung cancer. Early diagnosis and early treatment are important interventions for the prognosis of patients with endometrial cancer, but patients with advanced and recurrent endometrial cancer do not respond well to conventional radiotherapy, chemotherapy and hormone therapy, and the 5-year survival rate is worse than that of early endometrial cancer decline, affecting its survival rate. Therefore, exploring new treatment models and strategies and opening up new directions to improve the survival rate of endometrial cancer and benefit more patients has become a clinical focus. [0003] Currently, UCEC is clinica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/30G16B35/00G16B40/00G16B50/30C12Q1/6886C12N15/11
Inventor 王珂于敏
Owner TIANJIN TUMOR HOSPITAL
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