Preparation method of contrast agent, contrast agent and application of contrast agent
A technology of contrast agent and safe dose, applied in the fields of application, MRI/MRI contrast agent, medical science, etc., can solve the problems of high cost, easy to cause phlebitis, low blood pressure, etc., to reduce economic cost and facilitate large-scale Scale-diverse promotion and application, the effect of avoiding allergies
Pending Publication Date: 2022-04-22
吴诗熳
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In addition, exogenous contrast agents include iron- and manganese-containing contrast agents, and rapid injection of iron-containing contrast agents is likely to cause complications such as phlebitis and hypotension, and the cost is higher than that of gadolinium-containing contrast agents; have certain neurotoxicity
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[0028] In order to enable those skilled in the art to better understand the solutions of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention.
[0029] In some processes described in the specification and claims of the present invention and the above-mentioned drawings, a plurality of operations appearing in a specific order are contained, but it should be clearly understood that these operations may not be performed in the order in which they appear herein Execution or parallel execution, the serial numbers of the operations, such as 101, 103, etc., are only used to distinguish different operations, and the serial numbers themselves do not represent any execution order. Additionally, these processes can include more or fewer operations, and these operations can be performed sequentially or in parallel.
[0030] The f...
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The invention discloses a preparation method of a contrast agent, the contrast agent and application of the contrast agent, and aims to find a more effective implementation scheme of a magnetic resonance contrast agent, the preparation method of the contrast agent comprises the following steps: obtaining in-vitro blood containing oxyhemoglobin, the in-vitro blood is autoblood of a subject or qualified in-vitro blood which is the same as the blood type of the subject and meets clinical standard allogenic blood transfusion conditions; sodium nitrite with a preset safe dosage is added into the in-vitro blood, so that the sodium nitrite and the oxyhemoglobin are fully reacted, and the contrast agent containing the methemoglobin is obtained. The contrast agent is generated by using autologous blood or qualified in-vitro blood which is the same as the blood type of a subject and meets clinical standard allogenic blood transfusion conditions, so that adverse reactions such as allergy of a metal ion contrast agent are avoided, the economic cost is reduced to a certain extent, and large-scale diversified popularization and application are facilitated.
Description
technical field [0001] The invention relates to the field of a medical contrast agent, in particular, the invention relates to a preparation method of a contrast agent, a contrast agent and an application thereof. Background technique [0002] Magnetic Resonance Imaging (MRI) uses radio frequency pulses to excite atomic nuclei with non-zero spins in a magnetic field. After the radio frequency pulses stop, the nuclei relax. During the relaxation process, an induction coil is used to The signal is collected and reconstructed according to a certain mathematical method to form a mathematical image. Specifically, relaxation refers to the deflection of the macroscopic magnetization vector after the hydrogen nuclei of the water molecules in the subject are excited by radio frequency to absorb energy during the MRI process. When the radio frequency pulse is turned off, the hydrogen nuclei will re-arrange along the direction of the external magnetic field , the process of releasing ...
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IPC IPC(8): A61B5/055A61K49/06
CPCA61B5/055A61K49/06
Inventor 吴诗熳
Owner 吴诗熳