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Contrast agent preparation method, contrast agent and application thereof

A technology of contrast agent and nitric oxide, which is applied in the field of medical contrast agent, can solve the problems of phlebitis, hypotension, and high cost, and achieve the effect of facilitating large-scale and diversified promotion and application, reducing economic costs, and avoiding allergies

Pending Publication Date: 2022-04-22
吴诗熳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, exogenous contrast agents include iron- and manganese-containing contrast agents, and rapid injection of iron-containing contrast agents is likely to cause complications such as phlebitis and hypotension, and the cost is higher than that of gadolinium-containing contrast agents; have certain neurotoxicity

Method used

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  • Contrast agent preparation method, contrast agent and application thereof
  • Contrast agent preparation method, contrast agent and application thereof

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Embodiment 1

[0035] see figure 1 , figure 1 shows a schematic flow chart of a method for preparing a contrast agent according to an embodiment of the present invention, as shown in figure 1 As shown, a method for preparing a contrast agent according to an embodiment of the present invention includes the following steps:

[0036] Step S101: Obtain isolated blood containing oxyhemoglobin, wherein the isolated blood is the subject's autologous blood or qualified isolated blood with the same blood type as the subject that meets clinical standard allogeneic blood transfusion conditions.

[0037] In some embodiments, assuming that the isolated blood is provided by the subject, obtaining the isolated blood containing oxyhemoglobin includes the following steps:

[0038] Ex vivo blood that meets preset specifications is collected by presetting a blood collection device and using phlebotomy.

[0039] In some embodiments, the preset blood collection device includes a disposable blood collection ne...

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Abstract

The invention discloses a contrast agent preparation method, a contrast agent and application thereof, and aims to find a more effective implementation scheme of a magnetic resonance contrast agent, the contrast agent preparation method comprises the following steps: obtaining in-vitro blood containing oxyhemoglobin, the in-vitro blood is autoblood of a subject or qualified in-vitro blood which is the same as the blood type of the subject and meets clinical standard allogenic blood transfusion conditions; nitric oxide is introduced into the in-vitro blood, so that the reduced ferrous state of iron contained in the oxyhemoglobin is oxidized into a ferric iron state, and the contrast agent containing the methemoglobin is obtained. The contrast agent is generated by using autologous blood or qualified in-vitro blood which is the same as the blood type of a subject and meets clinical standard allogenic blood transfusion conditions, so that adverse reactions such as allergy of a metal ion contrast agent are avoided, the economic cost is reduced to a certain extent, and large-scale diversified popularization and application are facilitated.

Description

technical field [0001] The invention relates to the field of a medical contrast agent, in particular, the invention relates to a method for preparing a contrast agent, a contrast agent and an application thereof. Background technique [0002] Magnetic Resonance Imaging (MRI) uses radio frequency pulses to excite atomic nuclei with non-zero spins in a magnetic field. After the radio frequency pulses stop, the nuclei relax. During the relaxation process, an induction coil is used to The signal is collected and reconstructed according to a certain mathematical method to form a mathematical image. Specifically, relaxation refers to the deflection of the macroscopic magnetization vector after the hydrogen nuclei of the water molecules in the subject are excited by radio frequency to absorb energy during the MRI process. When the radio frequency pulse is turned off, the hydrogen nuclei will re-arrange along the direction of the external magnetic field , the process of releasing e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/14
CPCA61K49/14
Inventor 吴诗熳
Owner 吴诗熳