Contrast agent, and preparation method and application thereof

Abstract

The invention discloses a contrast agent, a preparation method of the contrast agent and application of the contrast agent, and aims to find a more effective implementation scheme of a magnetic resonance contrast agent, the preparation method of the contrast agent comprises the following steps: obtaining in-vitro blood containing oxyhemoglobin, the in-vitro blood is autoblood of a subject or qualified in-vitro blood which is the same as the blood type of the subject and meets clinical standard allogenic blood transfusion conditions; carbon monoxide is introduced into the in-vitro blood until oxyhemoglobin is saturated by carbon monoxide, and the contrast agent containing carbon monoxide hemoglobin is obtained. The contrast agent is generated by using autologous blood or qualified in-vitro blood which is the same as the blood type of a subject and meets clinical standard allogenic blood transfusion conditions, so that adverse reactions such as allergy of a metal ion contrast agent are avoided, the economic cost is reduced to a certain extent, and large-scale diversified popularization and application are facilitated.

Description

technical field [0001] The invention relates to the field of a medical contrast agent, in particular, the invention relates to a contrast agent, a preparation method of the contrast agent and an application thereof. Background technique [0002] Magnetic Resonance Imaging (MRI) uses radio frequency pulses to excite atomic nuclei with non-zero spins in a magnetic field. After the radio frequency pulses stop, the nuclei relax. During the relaxation process, an induction coil is used to The signal is collected and reconstructed according to a certain mathematical method to form a mathematical image. Specifically, relaxation refers to the deflection of the macroscopic magnetization vector after the hydrogen nuclei of the water molecules in the subject are excited by radio frequency to absorb energy during the MRI process. When the radio frequency pulse is turned off, the hydrogen nuclei will re-arrange along the direction of the external magnetic field , the process of releasin...

AI Technical Summary

Problems solved by technology

[0003] In order to enhance the difference in image signal intensity, exogenous contrast agents usually need to be injected during the existing MRI process, and the commonly used exogenous contrast agents are mainly gadolinium-containing contrast agents, which have the risk of causing kidney damage and deposition in the body, and this The contrast agent is only temporarily confined in the blood vessel, and after a few cardiac cycles, it will diffuse to the extravascular space, which may cause diagnostic bias

In addition, exogenous contrast agents include iron- and manganese-containing contrast agents, and rapid injection of iron-containing contrast agents is likely to cause complications such as phlebitis and hypotension, and the cost is higher than that of gadolinium-containing contrast agents; have certain neurotoxicity

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