The invention relates to a downward layered up-down staggered drift filling mining method. The downward layered up-down staggered drift filling mining method is realized through stope arrangement, mining preparation cutting, stoping, stope ventilation and stope filling, and comprises the following steps that firstly, a preparation layer is formed at the top of an ore body, a first layered drift is started to be stoped after the preparation layer drift is completely filled, a second layered drift is stoped after the first layered drift is completely filled, and after the second-layer drift is mined, a downward layered up-down staggered drift stope structure is formed; the next-layer drift and the previous-layer drift are staggered up and down by 3 m and are stoped at intervals, the distance is 5 m, the top of the drift is a filling body false top, the upper half parts of the two sides are filling bodies, the lower half parts are ore bodies, and the safety is high; the two sides of the access are not prone to caving, and stoping is safe and reliable; the access section is large, and the production capacity is high; the inlet road is stoped along the top plate of the upper layer, the stoping direction is easy to control, and the engineering quality is high; the stope production organization is simple; the stope is simple in structure, the accurate mining project is simple, and the accurate mining project amount is small; large trackless equipment can be used in the stope, so that the production efficiency of the stope is greatly improved; and the stope filling engineering system is simple.