The invention discloses a fully-segmented presplitting squeezing primary-blasting mining method. The method comprises the following steps of: 1, performing sublevel mining on slowly inclined thick and large crushed ore bodies; 2, arranging a stope free with a bottom structure along a direction vertical to the direction of the ore bodies; 3, using a trackless development mode of a lower plate outside-vein sublevel tunnel and an outside-vein concentrated winze; 4, constructing a full-section pre-control top tunnel serving as a shoring tunnel and a drilling tunnel; 5, performing presplit blasting so as to form the outline of the stope, squeezing and blasting so as to form a mine, and performing presplitting, squeezing and primary-blasting on the fully-segmented ore bodies to form the mine; 6, concentratively removing the ore by trackless equipment under a fully-segmented open stope; and 7, concentratively filling in a large scale after full segmentation. The method has the remarkable characteristics of high mining safety, simple process, low loss and depletion, high mechanical degree and mining strength, high production capability of the stope, high efficiency, low cost, low labor intensity and the like.