The invention discloses an approach open stope subsequent filling mining method for a gently inclined medium-thick ore body. The approach open stope subsequent filling mining method for the gently inclined medium-thick ore body comprises the following steps that panel layout is carried out, specifically, panel dividing is carried out in the direction of the ore body, and columns are arranged between panels; a plurality of strip-shaped approach stopes are arranged in each panel in the ore body inclination; ore removal roadways are arranged at the bottom layer outside the vein of the ore body inthe ore body inclination, ore removal transverse drifts are arranged at the bottom of ore pillars reserved at the lower ends of the panels, drilling roadways are arranged at the bottoms of the strip-shaped approach stopes in the panels, and the ore removal transverse drifts and drilling roadways separately communicate with the ore removal roadways; filling ventilation connection channels are arranged at the positions, near the upper panel vein of the ore body, of the inner parts of the columns to connect the strip-shaped approach stopes; extraction and ore removal are carried out, specifically, medium-deep hole drilling trolley is used for drilling upward fan-shaped blast holes in the drilling roadways, and centralized charge blasting is carried out; the blasted ore is discharged to a jack shaft through a scraper through the drilling roadways, the ore removal roadways and the ore removal transverse drifts; and filling is carried out, specifically, once the extraction of the strip-shaped approach stopes is completed, one-time filling concentrating is carried out. The approach open stope subsequent filling mining method for the gently inclined medium-thick ore body greatly reduces the amount of mining and cutting work and has high ore removal and transportation efficiency.