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Chitosan-based artificial rotator cuff patch and preparation method thereof

A technology of chitosan and chitosan microspheres, used in prostheses, coatings, tissue regeneration, etc., can solve local inflammation, foreign body reaction and other problems

Pending Publication Date: 2022-04-22
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although artificial rotator cuff mesh has biomechanical advantages, it has problems such as foreign body reaction or local inflammation

Method used

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  • Chitosan-based artificial rotator cuff patch and preparation method thereof
  • Chitosan-based artificial rotator cuff patch and preparation method thereof
  • Chitosan-based artificial rotator cuff patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation of embodiment 1 patch

[0043] The chitosan electrospun membrane containing TGF-β and the chitosan hydrogel containing aspirin or celecoxib are covered on the base layer of the PET patch to obtain the finished artificial rotator cuff patch.

[0044] Cut the PET patch into a predetermined length and soak it in 75wt% ethanol solution, and ultrasonically treat it for 30 minutes. After the ultrasound is finished, rinse the surface of the PET patch with deionized water to remove impurities on the surface of the PET patch; clean the PET patch The sheets were dried to constant weight in a vacuum oven at room temperature.

[0045] The chitosan electrospun fiber membrane loaded with TGF-β is made of chitosan microspheres and TGF-β as an electrospinning solution, and then electrospun. Chitosan microsphere carrier is made by the following steps:

[0046] Weigh 2g chitosan and dissolve in 100ml 0.2mol / L acetic acid solution. At the same time, take a certain amoun...

Embodiment 2

[0053] Embodiment 2 performance test

[0054] Grouping of animal experiments: a. PET group; b. PET chitosan coating loaded with anti-inflammatory and healing-promoting drugs group.

[0055] Weaving of the patch: The two ends of the patch are woven with sutures so that it can be used to suture the rotator cuff stump and fix the humeral head. The size of the patch after weaving is 10mm in length, 4mm in width, and 2mm in thickness, which is suitable for the rabbit infraspinatus tendon suture model. The sutured patch was subjected to biomechanical tests, which met the maximum demand of about 130N for rabbit infraspinatus muscle tear.

[0056] ① 2.5-3.5kg New Zealand white rabbits were anesthetized and skin-prepared for the shoulder joint. A parallel incision was made about 4 cm above the infraspinatus tendon, and blunt separation was performed layer by layer to expose the infraspinatus tendon. The infraspinatus muscle was resected close to the insertion point of the humerus, an...

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Abstract

The invention relates to a chitosan-based artificial rotator cuff patch, which comprises a rotator cuff patch body, a PET patch substrate layer, an anti-inflammatory drug loading layer containing one or more of aspirin and celecoxib, and a healing promoting drug loading layer containing one or more of VEGF and TGF beta, and realizes early inhibition of inflammatory response. In the repair period, blood vessel formation is promoted to achieve the effect of promoting graft integration.

Description

technical field [0001] The invention belongs to the field of tissue repair, and in particular relates to a chitosan-based artificial rotator cuff patch, which is used for the repair of the rotator cuff, inhibits the occurrence and development of inflammation, and is beneficial to further play the role of promoting healing, and a method for preparing the patch . Background technique [0002] Rotator cuff tears cause joint pain, decreased function, stiffness, and limited range of motion, and impose a substantial economic burden on society. A giant rotator cuff tear refers to a rotator cuff injury with a tear greater than 5 cm or involving ≥ 2 tendons. Currently, surgical repair is the main treatment. Some patients' postoperative shoulder function has been greatly improved, but the re-tear rate is high, up to 15% to 94%. The cause of re-tear is related to factors such as tear size, blood supply, fat infiltration, age, smoking, and muscle atrophy. Studies have shown that the ...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/18A61L27/20A61L27/54A61L27/50
CPCA61L27/18A61L27/20A61L27/54A61L27/50A61L2430/10A61L2430/34A61L2300/41A61L2300/414A61L2300/608A61L2300/61A61L2420/02A61L2420/06A61L2420/08A61L2300/602C08L67/02C08L5/10
Inventor 陈世益陈俊钟雨婷高寒孙路易余承瑄
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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