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Rifaximin liquid preparation

A technology of rifaximin and excipients, applied in the field of rifaximin liquid preparation, can solve the problems of low systemic utilization rate and the like

Pending Publication Date: 2022-04-26
バウシュ ヘルス アイルランド リミテッド
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, rifaximin has traditionally been neglected for the treatment of systemic infections caused by invasive organisms due to low systemic availability
Patient compliance is another concern, as low adsorption can lead to larger, more frequent dosing

Method used

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  • Rifaximin liquid preparation
  • Rifaximin liquid preparation
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Embodiment Construction

[0078] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0079] When ranges are used herein to describe, for example, amounts of a particular compound or ingredient, all combinations and subcombinations of ranges and specific embodiments therein are intended to be included. The use of the term "about" when referring to a number or numerical range means that the referenced number or numerical range is an approximation within experimental variability (or within statistical experimental error) and that therefore the number or value Ranges can vary. The term "comprising" (and related terms such as "containing" or "having" or "comprising") includes embodiments such as "consisting of" or "consisting essentially of" the described features An embodiment of any composition of matter, method, or process.

[0080] 1. Definition

[0081] "Rifaximin"...

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Abstract

Provided herein are pharmaceutical compositions that enhance the intestinal level of soluble rifaximin, formulations comprising the compositions, and their use in the treatment of one or more intestinal related disorders.

Description

[0001] related application [0002] This application claims priority to U.S. Provisional Application No. 62 / 904,790, filed September 24, 2019, and U.S. Provisional Application No. 63 / 044,447, filed June 26, 2020, the entire contents of each of which are incorporated by reference into this article. Background technique [0003] Rifaximin (eg, Xifaxan®) is an oral broad-spectrum antibiotic with antimicrobial activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Rifaximin is currently indicated for the treatment of traveler's diarrhea (TD), for maintaining remission of hepatic encephalopathy (HE), and for the treatment of irritable bowel syndrome with diarrhea (IBS-D). Other uses of rifaximin include, for example, the treatment of Clostridium difficile (C. difficile) infection, infectious diarrhea, small intestinal bacterial overgrowth (SIBO), inflammatory diseases, inflammatory bowel disease (IBD) and diverticular disease. Because rifaximin is largel...

Claims

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Application Information

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IPC IPC(8): A61K31/437A61K47/44A61K47/14A61K47/26A61K47/10A61K47/12A61K47/22A61K9/08A61K9/48A61P31/04A61P1/00A61P1/16A61P9/00A61P9/10A61P25/16A61P25/28A61P25/00A61P35/02
CPCA61K31/437A61K47/44A61K47/14A61K47/26A61K47/10A61K47/12A61K47/22A61K9/08A61K9/4858A61K9/4825A61K9/4808A61P31/04A61P1/00A61P1/16A61P9/00A61P9/10A61P25/16A61P25/28A61P25/00A61P35/02A61K9/4866A61K9/5031Y02A50/30
Inventor A·J·安杰尔K·R·帕瓦R·S·皮莱
Owner バウシュ ヘルス アイルランド リミテッド
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